M
Maxine A. Lesniak
Researcher at National Institutes of Health
Publications - 59
Citations - 5513
Maxine A. Lesniak is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Insulin & Receptor. The author has an hindex of 34, co-authored 59 publications receiving 5415 citations.
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Insulin interactions with its receptors: experimental evidence for negative cooperativity.
TL;DR: A simple method is reported to detect cooperative interactions in the binding of polypeptide hormones to their membrane receptors, and Insulin receptors on cultured lymphocytes and liver plasma membranes show negative cooperative interactions.
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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia.
Naoto Kubota,Kazuyuki Tobe,Yasuo Terauchi,Kazuhiro Eto,Toshimasa Yamauchi,Ryo Suzuki,Yoshiharu Tsubamoto,Kajuro Komeda,Ryosuke Nakano,Hiroshi Miki,Shinobu Satoh,Hisahiko Sekihara,Salvatore Sciacchitano,Maxine A. Lesniak,Shinichi Aizawa,Ryozo Nagai,Satoshi Kimura,Yasuo Akanuma,Simeon I. Taylor,Takashi Kadowaki +19 more
TL;DR: The results suggest that IRS-1 and IRS-2 may play different roles in the regulation of beta-cell mass and the function of individual beta-cells.
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Autoradiographic localization of insulin receptors in rat brain: prominence in olfactory and limbic areas.
TL;DR: The enrichment of insulin receptors in the olfactory and limbic systems, in addition to their prevalence in the strata occupied by the dendritic fields of principle neurons, suggests a neuromodulatory function for insulin in the brain.
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Human Orthologs of Yeast Vacuolar Protein Sorting Proteins Vps26, 29, and 35: Assembly into Multimeric Complexes
Carol Renfrew Haft,Maria de la Luz Sierra,Richard Bafford,Maxine A. Lesniak,Valarie A. Barr,Simeon I. Taylor +5 more
TL;DR: The cloning and characterization of human orthologs of three additional components of the retromer complex, including Vps26p, Vps29p, and Vps35p are reported, providing the first insights into the binding interactions among subunits of a putative mammalian retromers complex.
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Evolutionary origins of vertebrate hormones: substances similar to mammalian insulins are native to unicellular eukaryotes
TL;DR: The findings suggest that insulin did not arise evolutionarily in the intestinal or neural tissues of primitive vertebrates or complex invertebrates but rather has its molecular origins at least as far back as the simplest unicellular eukaryotes.