A review of cinnamaldehyde and its derivatives as antibacterial agents.

Smart copper oxide nanocrystals: Synthesis, characterization, electrochemical and potent antibacterial activity B Biointerfaces

The current emerging COVID-19 pandemic has caused a global impact on every major aspect of our societies It is known that SARS-Cov-2 can endure harsh environmental conditions for up to 72 h, which may contribute to its rapid spread Therefore, effective containment strategies, such as sanitizing, are critical Nanotechnology can represent an alternative to reduce the COVID-19 spread, particularly in critical areas, such as healthcare facilities and public places Nanotechnology-based products are effective at inhibiting different pathogens, including viruses, regardless of their drug-resistant profile, biological structure, or physiology Although there are several approved nanotechnology-based antiviral products, this work aims to highlight the use of nanomaterials as sanitizers for the prevention of the spread of mainly SARS-Cov-2 It has been widely demonstrated that nanomaterials are an alternative for sanitizing surfaces to inactivate the virus Also, antimicrobial nanomaterials can reduce the risk of secondary microbial infections on COVID-19 patients, as they inhibit the bacteria and fungi that can contaminate healthcare-related facilities Finally, cost-effective, easy-to-synthesize antiviral nanomaterials could reduce the burden of the COVID-19 on challenging environments and in developing countries

Nanotechnology as an Alternative to Reduce the Spread of COVID-19

The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc- and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, x-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.

https://www.mdpi.com/1999-4923/12/4/361/pdf

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

With the increasing demand for wound healing around the world, the level of medical equipment is also increasing, but sutures are still the preferred medical equipment for medical personnel to solve wound closures. Compared with the traditional sutures, the nanofiber sutures produced by combining the preparation technology of drug-eluting sutures have greatly improved both mechanical properties and biological properties. Electrospinning technology has attracted more attention as one of the most convenient and simple methods for preparing functional nanofibers and the related sutures. This review firstly discusses the structural classification of sutures and the performance analysis affecting the manufacture and use of sutures, followed by the discussion and classification of electrospinning technology, and then summarizes the relevant research on absorbable and non-absorbable sutures. Finally, several common polymers and biologically active substances used in creating sutures are concluded, the related applications of sutures are discussed, and the future prospects of electrospinning sutures are suggested.

/pdf/electrospun-medical-sutures-for-wound-healing-a-review-26fiopw9.pdf

Electrospun Medical Sutures for Wound Healing: A Review

Copper nanoparticles (CuNPs) have different structural properties and effective biological activities. One of the major proven applications of CuNPs is antimicrobial activity. The advantage of CuNPs is the control over particle size and compositions to provide additional applications. The synthesis of CuNPs through green synthesis, chemical, physical and biological methods is possible. The toxicity and stability of CuNPs are important for its use as antimicrobial agent. This work reviews the behavior of CuNPs and copper-based NPs as antimicrobial agents in different media under various conditions.

May Reda Ibrahim

Papers

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Copper-Based Nanoparticles, Their Chemistry and Antibacterial Properties: A Review