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Mayfong Mayxay
Researcher at Mahosot Hospital
Publications - 247
Citations - 14496
Mayfong Mayxay is an academic researcher from Mahosot Hospital. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 45, co-authored 214 publications receiving 10229 citations. Previous affiliations of Mayfong Mayxay include Churchill Hospital & University of Health Sciences Antigua.
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Journal ArticleDOI
Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis
Christopher J L Murray,Kevin S Ikuta,Fablina Sharara,Lucien Swetschinski,Gisela Robles Aguilar,Authia Gray,Chieh Fei Han,Catherine Bisignano,Puja C Rao,Eve E. Wool,Sarah Charlotte Johnson,Annie J. Browne,Michael G. Chipeta,Frederick Fell,Sean Hackett,Georgina Haines-Woodhouse,Bahar H. Kashef Hamadani,Emmanuelle A. P. Kumaran,Barney McManigal,Sureeruk Achalapong,Ramesh Agarwal,Samuel Akech,Samuel B. Albertson,John H Amuasi,Jason R. Andrews,Aleskandr Aravkin,Elizabeth A. Ashley,François-Xavier Babin,Freddie Bailey,Stephen Baker,Buddha Basnyat,Adrie Bekker,Rose G Bender,James A. Berkley,Adhisivam Bethou,Julia Bielicki,Suppawat Boonkasidecha,James Bukosia,Cristina Gardony Carvalheiro,Carlos A Castañeda-Orjuela,Vilada Chansamouth,Suman Chaurasia,Sara Chiurchiù,Fazle Rabbi Chowdhury,Rafai Clotaire Donatien,Aislinn Cook,Ben S. Cooper,Tim R. Cressey,Elia Criollo-Mora,Matthew Cunningham,Saffiatou Darboe,Nicholas P. J. Day,Maia De Luca,Klara Dokova,Angela Dramowski,Susanna Dunachie,Thuy Duong Bich,Tim Eckmanns,Daniel Eibach,Amir Emami,Nicholas A. Feasey,Natasha Fisher-Pearson,Karen Forrest,Coralith Garcia,Denise O Garrett,Petra Gastmeier,Ababi Zergaw Giref,Rachel C Greer,Vikas Gupta,Sebastian Haller,Andrea Haselbeck,Simon I. Hay,M. Holm,Susan Hopkins,Yingfen Hsia,Kenneth Iregbu,Jan Jacobs,Daniel Jarovsky,Fatemeh Javanmardi,Adam Jenney,Meera Khorana,Suwimon Khusuwan,Niranjan Kissoon,Elsa Kobeissi,Tomislav Kostyanev,Fiorella Krapp,Ralf Krumkamp,Ajay Kumar,Hmwe H Kyu,Cherry Lim,Kruy Lim,Direk Limmathurotsakul,Michael J. Loftus,Miles Lunn,Jianing Ma,Anand Manoharan,Florian Marks,Jürgen May,Mayfong Mayxay,Neema Mturi,Tatiana Múnera-Huertas,Patrick Musicha,Lilian Musila,Marisa Márcia Mussi-Pinhata,Ravi Naidu,Tomoka Nakamura,Ruchi Nanavati,Sushma Nangia,Paul N. Newton,Chanpheaktra Ngoun,Amanda Novotney,Davis Nwakanma,Christina W. Obiero,Theresa J. Ochoa,Antonio Olivas-Martinez,Piero Olliaro,Edna Ooko,Edgar Ortiz-Brizuela,Pradthana Ounchanum,Gi Deok Pak,Jose Luis Paredes,Anton Y. Peleg,Carlo Perrone,Thong Phe,Koukeo Phommasone,Nishad Plakkal,Alfredo Ponce-de-León,Mathieu Raad,Tanusha Ramdin,Sayaphet Rattanavong,Amy Riddell,Tamalee Roberts,Julie V. Robotham,Anna Roca,Victor D. Rosenthal,Kristina E. Rudd,Neal Russell,Helio S. Sader,Weerawut Saengchan,Janice W. Schnall,John Anthony G Scott,Samroeng Seekaew,Mike Sharland,Madhusudhan Shivamallappa,José Sifuentes-Osornio,A. John Simpson,Nicolas Steenkeste,Andrew J. Stewardson,Temenuga Stoeva,Nidanuch Tasak,Areerat Thaiprakong,Guy E. Thwaites,Caroline Tigoi,Claudia Turner,Paul Turner,H. Rogier van Doorn,Sithembiso Velaphi,Avina Vongpradith,Manivanh Vongsouvath,Huong X. Vu,Timothy R. Walsh,Judd L. Walson,Seymour Waner,Tri Wangrangsimakul,Prapass Wannapinij,Teresa M. Wozniak,Tracey E M W Young Sharma,Kalvin C. Yu,Peng Zheng,Benn Sartorius,Alan D. Lopez,Andy Stergachis,Catrin E. Moore,Christiane Dolecek,Mohsen Naghavi +174 more
TL;DR: This study provides the first comprehensive assessment of the global burden of AMR, as well as an evaluation of the availability of data, and estimates aggregated to the global and regional level.
Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
Olivo Miotto,Roberto Amato,Elizabeth A. Ashley,Bronwyn MacInnis,Jacob Almagro-Garcia,Chanaki Amaratunga,Pharath Lim,Daniel Mead,Samuel O. Oyola,Mehul Dhorda,Mallika Imwong,Charles J. Woodrow,Magnus Manske,Jim Stalker,Eleanor Drury,Susana Campino,Lucas Amenga-Etego,Thanh T-Nn.,Hien Tinh Tran,Pascal Ringwald,Delia Bethell,François Nosten,Aung Pyae Phyo,S Pukrittayakamee,Kesinee Chotivanich,Char Meng Chuor,Chea Nguon,Seila Suon,Sokunthea Sreng,Paul N. Newton,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Ye Htut,K T Han,Myat Phone Kyaw,MA Faiz,Caterina I. Fanello,M A Onyamboko,Olugbenga A. Mokuolu,Christopher G Jacob,Shannon Takala-Harrison,Christopher V. Plowe,Nicholas P. J. Day,Arjen M. Dondorp,Spencer Cca.,Gil McVean,Rick M. Fairhurst,Nicholas J. White,Dominic P. Kwiatkowski +49 more
TL;DR: Analysis of the fine structure of the parasite population showed that the fd, arps10, mdr2 and crt polymorphisms are markers of a genetic background on which kelch13 mutations are particularly likely to arise and that they correlate with the contemporary geographical boundaries and population frequencies of artemisinin resistance.
Journal ArticleDOI
Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data
Elizabeth A. Ashley,Francesca T. Aweeka,Karen I. Barnes,Quique Bassat,Steffen Borrmann,Steffen Borrmann,Prabin Dahal,Prabin Dahal,Tme Davis,Philippe Deloron,Mey Bouth Denis,Abdoulaye Djimde,Jean-François Faucher,Blaise Genton,Blaise Genton,Philippe J Guerin,Kamal Hamed,Eva Maria Hodel,Eva Maria Hodel,Liusheng Huang,Jullien,Harin Karunajeewa,Harin Karunajeewa,Kiechel,Poul-Erik Kofoed,Gilbert Lefèvre,Niklas Lindegardh,Kevin Marsh,Kevin Marsh,Andreas Mårtensson,Mayfong Mayxay,Mayfong Mayxay,Rose McGready,C Moreira,Paul N. Newton,Billy Ngasala,François Nosten,Christian Nsanzabana,Christian Nsanzabana,Sunil Parikh,Ric N. Price,Pascal Ringwald,Lars Rombo,Lars Rombo,Birgit Schramm,Carol Hopkins Sibley,Kasia Stepniewska,Johan Ursing,Michèle van Vugt,Michèle van Vugt,Nicholas J. White,Lesley Workman +51 more
TL;DR: Higher, more frequent, or prolonged dosage regimens should now be evaluated in very young children, particularly if malnourished, and in patients with hyperparasitemia, as well as patients in very low transmission intensity areas with emerging parasite resistance.
Journal ArticleDOI
Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia
Shannon Takala-Harrison,Christopher G Jacob,Cesar Arze,Michael P. Cummings,Joana C. Silva,Arjen M. Dondorp,Mark M. Fukuda,Tran Tinh Hien,Mayfong Mayxay,Mayfong Mayxay,Mayfong Mayxay,Harald Noedl,François Nosten,Myat Phone Kyaw,Nguyen Thanh Thuy Nhien,Mallika Imwong,Delia Bethell,Youry Se,Chanthap Lon,Stuart D. Tyner,David L. Saunders,Frédéric Ariey,Odile Mercereau-Puijalon,Didier Menard,Paul N. Newton,Paul N. Newton,Maniphone Khanthavong,Bouasy Hongvanthong,Peter Starzengruber,Hans-Peter Fuehrer,Paul Swoboda,Wasif A. Khan,Aung Pyae Phyo,Myaing Myaing Nyunt,Myat Htut Nyunt,Tyler S. Brown,Matthew Adams,Christopher S. Pepin,Jason A. Bailey,John C. Tan,Michael T. Ferdig,Taane G. Clark,Olivo Miotto,Bronwyn MacInnis,Dominic P. Kwiatkowski,Nicholas J. White,Pascal Ringwald,Christopher V. Plowe +47 more
TL;DR: While there was some evidence of spreading resistance, there was no evidence of resistance moving westward from Cambodia into Myanmar, and K13 appears to be a major determinant of artemisinin resistance throughout Southeast Asia.