M
Mayilvahanan Shanmugam
Researcher at Rutgers University
Publications - 21
Citations - 481
Mayilvahanan Shanmugam is an academic researcher from Rutgers University. The author has contributed to research in topics: Sarcolipin & Aggregatibacter actinomycetemcomitans. The author has an hindex of 10, co-authored 21 publications receiving 388 citations. Previous affiliations of Mayilvahanan Shanmugam include University of Medicine and Dentistry of New Jersey.
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Journal ArticleDOI
Increased sarcolipin expression and decreased sarco(endo)plasmic reticulum Ca2+ uptake in skeletal muscles of mouse models of Duchenne muscular dystrophy.
Joel S. Schneider,Mayilvahanan Shanmugam,James P. Gonzalez,Henderson Lopez,Richard Gordan,Diego Fraidenraich,Gopal J. Babu +6 more
TL;DR: The data suggest that sarcolipin upregulation is a common secondary alteration in all dystrophic muscles and contributes to the abnormal elevation of intracellular Ca2+ concentration via SERCA inhibition.
Journal ArticleDOI
Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation.
Mayilvahanan Shanmugam,Cristina E. Molina,Cristina E. Molina,Shumin Gao,Renaud Severac-Bastide,Rodolphe Fischmeister,Rodolphe Fischmeister,Gopal J. Babu +7 more
TL;DR: The selective downregulation of SLN and enhanced SR Ca( 2+) uptake in human AF suggest that SLN downregulation could play an important role in abnormal intracellular Ca(2+) cycling in atrial pathology.
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Angiotensin II Induces afterdepolarizations via reactive oxygen species and calmodulin kinase II signaling
Zhenghang Zhao,Nadezhda Fefelova,Mayilvahanan Shanmugam,Peter Bishara,Gopal J. Babu,Lai-Hua Xie +5 more
TL;DR: It is concluded that Ang II induces EADs via intracellular ROS production through NADPH oxidase, activation of CaMKII, and enhancement of I(Ca,L) and late I(Na), which were attenuated by losartan, apocynin, trolox, or KN-93.
Journal ArticleDOI
The Role of Exopolysaccharides in Oral Biofilms.
TL;DR: This review presents the current research on exopolysaccharides of oral microbes regarding their biosynthesis, regulation, contributions to biofilm formation and stability of the matrix, and immune evasion, as well as a potential nutrient source for species within a biofilm.
Journal ArticleDOI
Ablation of sarcolipin results in atrial remodeling
Lai-Hua Xie,Mayilvahanan Shanmugam,Ji Yeon Park,Zhenghang Zhao,Hairuo Wen,Bin Tian,Muthu Periasamy,Gopal J. Babu +7 more
TL;DR: Findings indicate that ablation of SLN results in increased SERCA activity and SR Ca(2+) load, which, in turn, could cause abnormal intracellular Ca( 2+) handling and atrial remodeling.