Author
Md. Abir Hasan
Bio: Md. Abir Hasan is an academic researcher from Sylhet Agricultural University. The author has contributed to research in topics: Chikungunya & Glycoprotein complex. The author has co-authored 1 publications.
Topics: Chikungunya, Glycoprotein complex
Papers
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TL;DR: In this article, the authors performed molecular docking and dynamics simulation to identify the top candidates for nsP3 macro domains, nsP2 protease, and envelope glycoprotein complex inhibitors, as well as to predict possible therapeutic candidates.
1 citations
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TL;DR: The general process of CADD is described, the viral proteins that play an essential role in the life cycle of the influenza A virus and can be used as therapeutic targets for anti-influenza drugs are described, and examples of drug screening of viral target proteins by applying the CADD approach are discussed.
Abstract: Influenza A is an acute respiratory infectious disease caused by the influenza A virus, which seriously threatens global human health and causes substantial economic losses every year. With the emergence of new viral strains, anti-influenza drugs remain the most effective treatment for influenza A. Research on traditional, innovative small-molecule drugs faces many challenges, while computer-aided drug design (CADD) offers opportunities for the rapid and effective development of innovative drugs. This literature review describes the general process of CADD, the viral proteins that play an essential role in the life cycle of the influenza A virus and can be used as therapeutic targets for anti-influenza drugs, and examples of drug screening of viral target proteins by applying the CADD approach. Finally, the main limitations of current CADD strategies in anti-influenza drug discovery and the field’s future directions are discussed.
8 citations