M
Megan F. Cole
Researcher at Georgia Institute of Technology
Publications - 12
Citations - 9243
Megan F. Cole is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 9, co-authored 12 publications receiving 8843 citations. Previous affiliations of Megan F. Cole include Massachusetts Institute of Technology.
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Journal ArticleDOI
Core transcriptional regulatory circuitry in human embryonic stem cells.
Laurie A. Boyer,Tong Ihn Lee,Megan F. Cole,Sarah E. Johnstone,Stuart S. Levine,Jacob P. Zucker,Matthew G. Guenther,Roshan M. Kumar,Heather L. Murray,Richard G. Jenner,David K. Gifford,David K. Gifford,David K. Gifford,Douglas A. Melton,Douglas A. Melton,Rudolf Jaenisch,Richard A. Young,Richard A. Young +17 more
TL;DR: Insight is provided into the transcriptional regulation of stem cells and how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal and how they collaborate to form regulatory circuitry consisting of autoregulatory and feedforward loops.
Journal ArticleDOI
Control of developmental regulators by Polycomb in human embryonic stem cells.
Tong Ihn Lee,Richard G. Jenner,Laurie A. Boyer,Matthew G. Guenther,Stuart S. Levine,Roshan M. Kumar,Brett Chevalier,Sarah E. Johnstone,Megan F. Cole,Kyoichi Isono,Haruhiko Koseki,Takuya Fuchikami,Kuniya Abe,Heather L. Murray,Jacob P. Zucker,Bingbing Yuan,George W. Bell,Elizabeth Herbolsheimer,Nancy M. Hannett,Kaiming Sun,Duncan T. Odom,Arie P. Otte,Thomas L. Volkert,David P. Bartel,Douglas A. Melton,David K. Gifford,David K. Gifford,Rudolf Jaenisch,Richard A. Young +28 more
TL;DR: It is found that PRC2 target genes are preferentially activated during ES cell differentiation and that the ES cell regulators OCT4, SOX2, and NANOG cooccupy a significant subset of these genes.
Journal ArticleDOI
Genome-wide map of nucleosome acetylation and methylation in yeast.
Dmitry K. Pokholok,Christopher T. Harbison,Stuart S. Levine,Megan F. Cole,Nancy M. Hannett,Tong Ihn Lee,George W. Bell,Kimberly Walker,P. Alex Rolfe,Elizabeth Herbolsheimer,Julia Zeitlinger,Fran Lewitter,David K. Gifford,Richard A. Young +13 more
TL;DR: These maps take into account changes in nucleosome occupancy at actively transcribed genes and, in doing so, revise previous assessments of the modifications associated with gene expression, providing the foundation for further understanding the roles of chromatin in gene expression and genome maintenance.
Journal ArticleDOI
Tcf3 is an integral component of the core regulatory circuitry of embryonic stem cells.
TL;DR: This work reports that a terminal component of the canonical Wnt pathway in ES cells, the transcription factor T-cell factor-3 (Tcf3), co-occupies promoters throughout the genome in association with the pluripotency regulators Oct4 and Nanog.
Journal ArticleDOI
Transcriptional role of cyclin D1 in development revealed by a genetic–proteomic screen
Frédéric Bienvenu,Siwanon Jirawatnotai,Siwanon Jirawatnotai,Joshua E. Elias,Joshua E. Elias,Clifford A. Meyer,Karolina Mizeracka,Alexander Marson,Garrett M. Frampton,Megan F. Cole,Duncan T. Odom,Junko Odajima,Yan Geng,Agnieszka Zagozdzon,Marie Jecrois,Richard A. Young,X. Shirley Liu,Constance L. Cepko,Steven P. Gygi,Piotr Sicinski +19 more
TL;DR: In this article, a high-throughput mass spectrometry approach was used to search for cyclin D1-binding proteins in different mouse organs, including the Notch1 gene.