Author
Mehdi Raei
Other affiliations: Tehran University of Medical Sciences, Qom University of Medical Sciences, Kerman Medical University
Bio: Mehdi Raei is an academic researcher from Baqiyatallah University of Medical Sciences. The author has contributed to research in topics: Epidemiology & Cancer. The author has an hindex of 7, co-authored 36 publications receiving 140 citations. Previous affiliations of Mehdi Raei include Tehran University of Medical Sciences & Qom University of Medical Sciences.
Topics: Epidemiology, Cancer, Mental health, Health care, Mortality rate
Papers
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University of Tabriz1, University of Tehran2, Islamic Azad University3, Shahid Beheshti University of Medical Sciences and Health Services4, Comenius University in Bratislava5, Baqiyatallah University of Medical Sciences6, University of Maryland, College Park7, Kerman Medical University8, Kermanshah University of Medical Sciences9, National University of Singapore10, Sabancı University11
TL;DR: This review focuses on microRNAs (miRNAs) and their regulatory effect on epithelial-to-mesenchymal transition (EMT) mechanisms that can regulate metastasis ofadder cancer cells.
Abstract: Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors including environmental and genetic ones participate in BC development. Metastasis of BC cells into neighboring and distant tissues significantly reduces overall survival of patients with this life-threatening disorder. Recently, studies have focused on revealing molecular pathways involved in metastasis of BC cells, and in this review, we focus on microRNAs (miRNAs) and their regulatory effect on epithelial-to-mesenchymal transition (EMT) mechanisms that can regulate metastasis. EMT is a vital process for migration of BC cells, and inhibition of this mechanism restricts invasion of BC cells. MiRNAs are endogenous non-coding RNAs with 19-24 nucleotides capable of regulating different cellular events, and EMT is one of them. In BC cells, miRNAs are able to both induce and/or inhibit EMT. For regulation of EMT, miRNAs affect different molecular pathways such as transforming growth factor-beta (TGF-β), Snail, Slug, ZEB1/2, CD44, NSBP1, which are, discussed in detail this review. Besides, miRNA/EMT axis can also be regulated by upstream mediators such as lncRNAs, circRNAs and targeted by diverse anti-tumor agents. These topics are also discussed here to reveal diverse molecular pathways involved in migration of BC cells and strategies to target them to develop effective therapeutics.
92 citations
Sabancı University1, Islamic Azad University, Science and Research Branch, Tehran2, Islamic Azad University3, University of Tehran4, Baqiyatallah University of Medical Sciences5, Commonwealth Scientific and Industrial Research Organisation6, Harvard University7, Iran University of Medical Sciences8, Palacký University, Olomouc9, University of the Basque Country10, National University of Singapore11, Scotland's Rural College12, University of British Columbia13, Istituto Italiano di Tecnologia14, Georgia Regents University15
TL;DR: Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance.
79 citations
Sabancı University1, University of Tehran2, Shiraz University of Medical Sciences3, Baqiyatallah University of Medical Sciences4, Islamic Azad University5, Iran University of Medical Sciences6, Kerman Medical University7, Kermanshah University of Medical Sciences8, Georgia Regents University9, Istituto Italiano di Tecnologia10
TL;DR: Co-delivery of natural compounds/siRNA using nanovehicles as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells.
Abstract: Chemotherapy using natural compounds, such as resveratrol, curcumin, paclitaxel, docetaxel, etoposide, doxorubicin, and camptothecin, is of importance in cancer therapy because of the outstanding therapeutic activity and multitargeting capability of these compounds. However, poor solubility and bioavailability of natural compounds have limited their efficacy in cancer therapy. To circumvent this hurdle, nanocarriers have been designed to improve the antitumor activity of the aforementioned compounds. Nevertheless, cancer treatment is still a challenge, demanding novel strategies. It is well-known that a combination of natural products and gene therapy is advantageous over monotherapy. Delivery of multiple therapeutic agents/small interfering RNA (siRNA) as a potent gene-editing tool in cancer therapy can maximize the synergistic effects against tumor cells. In the present review, co-delivery of natural compounds/siRNA using nanovehicles are highlighted to provide a backdrop for future research.
60 citations
Islamic Azad University, Science and Research Branch, Tehran1, Sabancı University2, Islamic Azad University3, University of Tehran4, Baqiyatallah University of Medical Sciences5, Istituto Italiano di Tecnologia6, Kermanshah University of Medical Sciences7, Harvard University8, University of Johannesburg9
TL;DR: In this paper, the regulatory impact of miRNA-338-3p on cancer growth and migration is discussed and it seems that miRNA has dual role in cancer chemotherapy, acting as tumor-promoting or tumor-suppressor factor.
49 citations
TL;DR: In this article, the authors considered a wide variety of risk factors for lung cancer development such as smoking, air pollution and family history, and found that genetic and epigenetic factors are also potential players in lung cancer progression.
29 citations
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TL;DR: Joint structure and function a comprehensive analysis now will lead you to always think more and more and this book will be always right for you.
Abstract: Want to get experience? Want to get any ideas to create new things in your life? Read joint structure and function a comprehensive analysis now! By reading this book as soon as possible, you can renew the situation to get the inspirations. Yeah, this way will lead you to always think more and more. In this case, this book will be always right for you. When you can observe more about the book, you will know why you need this.
268 citations
01 Jan 2020
TL;DR: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.
Abstract: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
155 citations
TL;DR: This review sheds light on the growing interest in self-assembled peptides and proteins and their burgeoning applications in cancer treatment and immunotherapy.
113 citations
Sabancı University1, Islamic Azad University, Science and Research Branch, Tehran2, Islamic Azad University3, University of Tehran4, Baqiyatallah University of Medical Sciences5, Commonwealth Scientific and Industrial Research Organisation6, Harvard University7, Iran University of Medical Sciences8, Palacký University, Olomouc9, University of the Basque Country10, National University of Singapore11, Scotland's Rural College12, University of British Columbia13, Istituto Italiano di Tecnologia14, Georgia Regents University15
TL;DR: Hyaluronic acid-based advanced materials provide a platform for the co-delivery of genes and drugs along with DOX to enhance the efficacy of anti-cancer therapy and overcome chemoresistance.
79 citations
TL;DR: An overview of newly-developed nanocarriers and their potential applications and limitations in various fields of dentistry and oral medicine can be found in this article, where the authors discuss their potential application and limitations.
Abstract: The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults They are also common sites for pathological and cancerous changes The effectiveness of conventional locally-administered medications against diseases affecting these oral milieus may be compromised by constant salivary flow For systemically-administered medications, drug resistance and adverse side-effects are issues that need to be resolved New strategies for drug delivery have been investigated over the last decade to overcome these obstacles Synthesis of nanoparticle-containing agents that promote healing represents a quantum leap in ensuring safe, efficient drug delivery to the affected tissues Micro/nanoencapsulants with unique structures and properties function as more favorable drug-release platforms than conventional treatment approaches The present review provides an overview of newly-developed nanocarriers and discusses their potential applications and limitations in various fields of dentistry and oral medicine
71 citations