M
Mehul Dhorda
Researcher at University of Oxford
Publications - 100
Citations - 6902
Mehul Dhorda is an academic researcher from University of Oxford. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 32, co-authored 81 publications receiving 5371 citations. Previous affiliations of Mehul Dhorda include Chulalongkorn University & University of Maryland, Baltimore.
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Journal ArticleDOI
Spread of Artemisinin Resistance in Plasmodium falciparum Malaria
Elizabeth A. Ashley,Mehul Dhorda,Rick M. Fairhurst,Chanaki Amaratunga,Pharath Lim,Seila Suon,Sokunthea Sreng,Jennifer M. Anderson,Mao S,Sam B,Chantha Sopha,Char Meng Chuor,Chea Nguon,Siv Sovannaroth,Sasithon Pukrittayakamee,Podjanee Jittamala,Kesinee Chotivanich,K Chutasmit,C Suchatsoonthorn,R Runcharoen,Tran Tinh Hien,Nguyen Thuy-Nhien,Thanh Nv,Nguyen Hoan Phu,Ye Htut,Han Kt,Kyin Hla Aye,Olugbenga A. Mokuolu,Rasaq Olaosebikan,Olaleke Oluwasegun Folaranmi,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Paul N. Newton,M A Onyamboko,Caterina I. Fanello,Antoinette Tshefu,Neelima Mishra,Neena Valecha,Aung Pyae Phyo,François Nosten,Yi P,Rupam Tripura,Steffen Borrmann,Mahfudh Bashraheil,Judy Peshu,M A Faiz,Aniruddha Ghose,M A Hossain,Rasheda Samad,M. R. Rahman,Manal Hasan,Ashraful Islam,Olivo Miotto,Roberto Amato,Bronwyn MacInnis,Jim Stalker,Dominic P. Kwiatkowski,Zbynek Bozdech,Atthanee Jeeyapant,Phaik Yeong Cheah,Tharisara Sakulthaew,Jeremy Chalk,Benjamas Intharabut,Kamolrat Silamut,Lee Sj,Benchawan Vihokhern,Chanon Kunasol,Mallika Imwong,Joel Tarning,Taylor Wj,Shunmay Yeung,Charles J. Woodrow,Jennifer A. Flegg,Debashish Das,Jennifer L. Smith,Meera Venkatesan,Christopher V. Plowe,Kasia Stepniewska,Philippe J Guerin,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas J. White +82 more
TL;DR: Prolonged courses of artemisinin-based combination therapies are currently efficacious in areas where standard 3-day treatments are failing, and the incidence of pretreatment and post-treatment gametocytemia was higher among patients with slow parasite clearance, suggesting greater potential for transmission.
Journal ArticleDOI
Genetic architecture of artemisinin-resistant Plasmodium falciparum.
Olivo Miotto,Roberto Amato,Elizabeth A. Ashley,Bronwyn MacInnis,Jacob Almagro-Garcia,Chanaki Amaratunga,Pharath Lim,Daniel Mead,Samuel O. Oyola,Mehul Dhorda,Mallika Imwong,Charles J. Woodrow,Magnus Manske,Jim Stalker,Eleanor Drury,Susana Campino,Lucas Amenga-Etego,Thanh T-Nn.,Hien Tinh Tran,Pascal Ringwald,Delia Bethell,François Nosten,Aung Pyae Phyo,S Pukrittayakamee,Kesinee Chotivanich,Char Meng Chuor,Chea Nguon,Seila Suon,Sokunthea Sreng,Paul N. Newton,Mayfong Mayxay,Maniphone Khanthavong,Bouasy Hongvanthong,Ye Htut,K T Han,Myat Phone Kyaw,MA Faiz,Caterina I. Fanello,M A Onyamboko,Olugbenga A. Mokuolu,Christopher G Jacob,Shannon Takala-Harrison,Christopher V. Plowe,Nicholas P. J. Day,Arjen M. Dondorp,Spencer Cca.,Gil McVean,Rick M. Fairhurst,Nicholas J. White,Dominic P. Kwiatkowski +49 more
TL;DR: Analysis of the fine structure of the parasite population showed that the fd, arps10, mdr2 and crt polymorphisms are markers of a genetic background on which kelch13 mutations are particularly likely to arise and that they correlate with the contemporary geographical boundaries and population frequencies of artemisinin resistance.
Journal ArticleDOI
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker
Kyaw Myo Tun,Mallika Imwong,Khin Maung Lwin,Aye A. Win,Tin Maung Hlaing,Thaung Hlaing,Khin Lin,Myat Phone Kyaw,Katherine Plewes,Katherine Plewes,M. Abul Faiz,Mehul Dhorda,Phaik Yeong Cheah,Phaik Yeong Cheah,Sasithon Pukrittayakamee,Elizabeth A. Ashley,Elizabeth A. Ashley,Tim J. Anderson,Shalini Nair,Marina McDew-White,Jennifer A. Flegg,Eric P. M. Grist,Philippe Allard Guérin,Richard J. Maude,Richard J. Maude,Frank Smithuis,Arjen M. Dondorp,Arjen M. Dondorp,Nicholas P. J. Day,Nicholas P. J. Day,François Nosten,Nicholas J. White,Nicholas J. White,Charles J. Woodrow,Charles J. Woodrow +34 more
TL;DR: Assessment of the spread of artemisinin-resistant P falciparum in Myanmar finds Artemisinin resistance extends across much of Myanmar, and Appropriate therapeutic regimens should be tested urgently and implemented comprehensively if spread of warfarin resistance to other regions is to be avoided.
Journal ArticleDOI
Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
Sachel Mok,Elizabeth A. Ashley,Elizabeth A. Ashley,Pedro Eduardo Ferreira,Lei Zhu,Zhaoting Lin,Tomas Yeo,Kesinee Chotivanich,Mallika Imwong,Sasithon Pukrittayakamee,Mehul Dhorda,Mehul Dhorda,Mehul Dhorda,Chea Nguon,Pharath Lim,Chanaki Amaratunga,Seila Suon,Tran Tinh Hien,Ye Htut,M. Abul Faiz,Marie A. Onyamboko,Mayfong Mayxay,Mayfong Mayxay,Paul N. Newton,Paul N. Newton,Paul N. Newton,Rupam Tripura,Charles J. Woodrow,Charles J. Woodrow,Olivo Miotto,Olivo Miotto,Olivo Miotto,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,François Nosten,François Nosten,Nicholas P. J. Day,Nicholas P. J. Day,Peter R. Preiser,Nicholas J. White,Nicholas J. White,Arjen M. Dondorp,Arjen M. Dondorp,Rick M. Fairhurst,Zbynek Bozdech +44 more
TL;DR: Analysis of in vivo transcriptomes of P. falciparum isolates from patients with acute malaria found that artemisinin resistance is associated with increased expression of unfolded protein response (UPR) pathways involving the major PROSC and TRiC chaperone complexes.
Journal ArticleDOI
The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study
Mallika Imwong,Kanokon Suwannasin,Chanon Kunasol,Kreepol Sutawong,Mayfong Mayxay,Mayfong Mayxay,Huy Rekol,Frank Smithuis,Tin Maung Hlaing,Kyaw Myo Tun,Rob W. van der Pluijm,Rob W. van der Pluijm,Rupam Tripura,Olivo Miotto,Olivo Miotto,Didier Menard,Mehul Dhorda,Nicholas P. J. Day,Nicholas P. J. Day,Nicholas J. White,Nicholas J. White,Arjen M. Dondorp,Arjen M. Dondorp +22 more
TL;DR: The results suggest that the dominant artemisinin-resistant P falciparum C580Y lineage probably arose in western Cambodia and then spread to Thailand and Laos, outcompeting other parasites and acquiring piperaquine resistance.