M
Mei Hui Liu
Researcher at National University of Singapore
Publications - 9
Citations - 1911
Mei Hui Liu is an academic researcher from National University of Singapore. The author has contributed to research in topics: Chromatin & Promoter. The author has an hindex of 6, co-authored 7 publications receiving 1719 citations. Previous affiliations of Mei Hui Liu include Agency for Science, Technology and Research & Genome Institute of Singapore.
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Journal ArticleDOI
An oestrogen-receptor-α-bound human chromatin interactome
Melissa J. Fullwood,Mei Hui Liu,You Fu Pan,Jun Liu,Han Xu,Yusoff Bin Mohamed,Yuriy L. Orlov,Stoyan Velkov,Andrea Ho,Poh Huay Mei,Elaine G.Y. Chew,Phillips Yao Hui Huang,Willem Welboren,Yuyuan Han,Hong Sain Ooi,Pramila N. Ariyaratne,Vinsensius B. Vega,Yanquan Luo,Peck Yean Tan,Pei Ye Choy,K. D. Senali Abayratna Wansa,Bing Zhao,Kar Sian Lim,Shi Chi Leow,Jit Sin Yow,Roy Joseph,Haixia Li,Kartiki V. Desai,Jane S. Thomsen,Yew Kok Lee,R. Krishna Murthy Karuturi,Thoreau Herve,Guillaume Bourque,Hendrik G. Stunnenberg,Xiaoan Ruan,Valere Cacheux-Rataboul,Wing-Kin Sung,Wing-Kin Sung,Edison T. Liu,Chia-Lin Wei,Edwin Cheung,Edwin Cheung,Edwin Cheung,Yijun Ruan,Yijun Ruan +44 more
TL;DR: It is proposed that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes and is described as a new strategy, chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) for the de novo detection of global Chromatin interactions.
Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal
You Fu Pan,Mei Hui Liu,Bing Zhao,Shuzhen Hong,Peck Yean Tan,Kar Sian Lim,Guillaume Bourque,Edison T. Liu,Edwin Cheung +8 more
TL;DR: In this article, the authors examined whether ER binding sites that are located distal from the transcription start sites of estrogen target genes are functionally relevant and found that ERs occupied at the distal sites are capable of communicating with ERs bound at the proximal promoter region, possibly via long range chromosome looping.
Journal ArticleDOI
Regulation of Estrogen Receptor-mediated Long Range Transcription via Evolutionarily Conserved Distal Response Elements
You Fu Pan,K. D. Senali Abayratna Wansa,Mei Hui Liu,Bing Zhao,Shuzhen Hong,Peck Yean Tan,Kar Sian Lim,Guillaume Bourque,Edison T. Liu,Edwin Cheung,Edwin Cheung,Edwin Cheung +11 more
TL;DR: The data indicate that distal ER binding sites are bona fide transcriptional enhancers that are involved in long range chromosomal interaction, transcription complex formation, and distinct structural modifications of chromatin across large genomic spans.
Journal ArticleDOI
Adipocyte Long-Noncoding RNA Transcriptome Analysis of Obese Mice Identified Lnc-Leptin, Which Regulates Leptin.
Kinyui Alice Lo,Kinyui Alice Lo,Shiqi Huang,Arcinas Camille Esther Walet,Zhi-chun Zhang,Melvin Khee-Shing Leow,Mei Hui Liu,Lei Sun,Lei Sun +8 more
TL;DR: A comprehensive transcriptome study in adipocytes isolated from interscapular brown, inguinal, and epididymal white adipose tissue in diet-induced obese mice revealed a set of obesity-dysregulated lncRNAs, many of which exhibit dynamic changes in the fed versus fasted state, potentially serving as novel molecular markers of adipose energy status.
Journal ArticleDOI
An AR-ERG transcriptional signature defined by long-range chromatin interactomes in prostate cancer cells.
Zhizhuo Zhang,Kern Rei Chng,Shreyas Lingadahalli,Zikai Chen,Zikai Chen,Mei Hui Liu,Huy Hoang Do,Shaojiang Cai,Nicola J. Rinaldi,Huay Mei Poh,Guoliang Li,Guoliang Li,Ying Ying Sung,Charlie L. Heng,Leighton J. Core,Si Kee Tan,Xiaoan Ruan,John T. Lis,Manolis Kellis,Manolis Kellis,Yijun Ruan,Wing-Kin Sung,Wing-Kin Sung,Edwin Cheung,Edwin Cheung +24 more
TL;DR: A novel framework to profile long-range chromatin interactions associated with AR and its collaborative transcription factor, erythroblast transformation-specific related gene (ERG), using chromatin interaction analysis by paired-end tag (ChIA-PET).