Meihua Liang

TL;DR: This study demonstrated that a wide variety of RNA species are embedded in the circulating vesicles and suggested that the highly abundant miRNAs may play an important role in biological functions such as protein phosphorylation, RNA splicing, chromosomal abnormality, and angiogenesis.

TL;DR: Blood-based small RNAs circulating in blood could be used to predict clinical outcomes in late-stage prostate cancer patients and plasma exosomal miRNAs miR-1290 and -375 are promising prognostic biomarkers for CRPC patients are identified.

TL;DR: This review of recent publications involving extracellular miRNA profiling studies in three representative urologic cancers, including: prostate cancer, bladder cancer, and renal cell carcinoma, focuses on the diagnostic, prognostic, and therapeutic potential of these miRNAs in biological fluids, such as serum, plasma, and urine.

TL;DR: Six aberrantly expressed plasma exosomal miRNAs may be used as diagnostic biomarkers to differentiate thyroid nodules from healthy individuals and combined miRNA panels showed increased diagnostic sensitivities and specificities compared to single miRNA markers.

TL;DR: Plasma exosomal miRNAs provide an easily accessible resource for biomarker development in prognosis of advanced prostate cancer and miR-30a/e-5p are qualified endogenous references for real-time qPCR.