Melanie Denizot

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: A rapid innate immune antiviral response was demonstrated by robust dendritic/NK/CD4/CD8 cell activation and accompanied by a rather weak Th1/Th2 cytokine response in both groups, and Interestingly, the antiviral immune response witnessed by high levels of IFN-α mRNA in PBMCs and circulating IL-12 persisted for months only in the chronic group.

TL;DR: The capacity of CHIKV to infect neurons and glial cells, delineate the fundamental innate (intrinsic) immune defence mechanisms to protect from infection and argue about the possible mechanisms involved in the encephalopathy are described.

TL;DR: A novel infectious mechanism by which CHIKV invades host cells and escapes the host response is described, which mobilizes the apoptotic machinery to invade host cell defenses.

TL;DR: Evidence is provided that hallmarks of autophagy are specifically found in HEK and may play a promoting role in ChikV replication, and it is found that inhibition of Autophagy, either by biochemical reagent and RNA interference, dramatically decreases ChkV replication.