M
Melanie Donahue
Researcher at Broad Institute
Publications - 4
Citations - 3020
Melanie Donahue is an academic researcher from Broad Institute. The author has contributed to research in topics: Replication protein A & Cohesin. The author has an hindex of 4, co-authored 4 publications receiving 1630 citations. Previous affiliations of Melanie Donahue include Massachusetts Institute of Technology.
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Journal ArticleDOI
A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles.
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Sarah A. Johnson,Nicholas J. Lyons,Alice H. Berger,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,David Y. Takeda,Roger Hu,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Peyton Greenside,Nathanael S. Gray,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +64 more
TL;DR: The expanded CMap is reported, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Posted ContentDOI
A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles
Aravind Subramanian,Rajiv Narayan,Steven M. Corsello,David Peck,Ted Natoli,Xiaodong Lu,Joshua Gould,John F. Davis,Andrew A. Tubelli,Jacob K. Asiedu,David L. Lahr,Jodi E. Hirschman,Zihan Liu,Melanie Donahue,Bina Julian,Mariya Khan,David Wadden,Ian Smith,Daniel D. Lam,Arthur Liberzon,Courtney Toder,Mukta Bagul,Marek Orzechowski,Oana M. Enache,Federica Piccioni,Alice H. Berger,Alykhan F. Shamji,Angela N. Brooks,Anita Vrcic,Corey Flynn,Jacqueline Rosains,David Y. Takeda,Desiree Davison,Justin Lamb,Kristin Ardlie,Larson Hogstrom,Nathanael S. Gray,Paul A. Clemons,Serena J. Silver,Xiaoyun Wu,Wen-Ning Zhao,Willis Read-Button,Xiaohua Wu,Stephen J. Haggarty,Lucienne Ronco,Jesse S. Boehm,Stuart L. Schreiber,John G. Doench,Joshua A. Bittker,David E. Root,Bang Wong,Todd R. Golub +51 more
TL;DR: A new, low-cost, high throughput reduced representation expression profiling method, L1000, is shown to be highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts.
Journal ArticleDOI
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition
Cory M. Johannessen,Laura A. Johnson,Laura A. Johnson,Laura A. Johnson,Federica Piccioni,Aisha Townes,Dennie T. Frederick,Melanie Donahue,Rajiv Narayan,Keith T. Flaherty,Jennifer A. Wargo,David E. Root,Levi A. Garraway,Levi A. Garraway +13 more
TL;DR: Systematic gain-of-function resistance studies suggest that oncogenic dysregulation of a melanocyte lineage dependency can cause resistance to RAF–MEK–ERK inhibition, which may be overcome by combining signalling- and chromatin-directed therapeutics.
Journal ArticleDOI
Cohesin mutations alter DNA damage repair and chromatin structure and create therapeutic vulnerabilities in MDS/AML
Zuzana Tothova,Zuzana Tothova,Anne-Laure Valton,Rebecca A. Gorelov,Mounica Vallurupalli,Mounica Vallurupalli,John M. Krill-Burger,Amie Holmes,Catherine C. Landers,J. Erika Haydu,Edyta Malolepsza,Christina R. Hartigan,Melanie Donahue,Katerina D. Popova,Sebastian Koochaki,Sergey V. Venev,Jeanne F Rivera,Edwin Chen,Kasper Lage,Monica Schenone,Alan D. D'Andrea,Steven A. Carr,Elizabeth A. Morgan,Job Dekker,Job Dekker,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +27 more
TL;DR: In this paper, the cohesin complex plays an essential role in chromosome maintenance and transcriptional regulation, and DNA damage repair and replication are identified as genetic dependencies in cohesIN-mutant cells.