M
Melanie Sticker
Researcher at Friedrich Miescher Institute for Biomedical Research
Publications - 5
Citations - 4219
Melanie Sticker is an academic researcher from Friedrich Miescher Institute for Biomedical Research. The author has contributed to research in topics: P70-S6 Kinase 1 & Insulin receptor. The author has an hindex of 5, co-authored 5 publications receiving 4078 citations.
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Journal ArticleDOI
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um,Francesca Frigerio,Mitsuhiro Watanabe,Frédéric Picard,Manel Joaquin,Melanie Sticker,Stefano Fumagalli,Peter R. Allegrini,Sara C. Kozma,Sara C. Kozma,Johan Auwerx,George Thomas +11 more
TL;DR: It is reported that S6K1-deficient mice are protected against obesity owing to enhanced β-oxidation, however on a high fat diet, levels of glucose and free fatty acids still rise in S6k1- deficient mice, resulting in insulin receptor desensitization.
Journal Article
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.]
Sung Hee Um,Francesca Frigerio,Mitsuhiro Watanabe,Frédéric Picard,Manel Joaquin,Melanie Sticker,Stefano Fumagalli,Peter R. Allegrini,Sara C. Kozma,Johan Auwerx +9 more
TL;DR: In this article, S6K1-deficient mice are protected against obesity owing to enhanced β-oxidation, but on a high fat diet, levels of glucose and free fatty acids still rise in S6k1-dependent mice, resulting in insulin receptor desensitization.
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S6K1(-/-)/S6K2(-/-) mice exhibit perinatal lethality and rapamycin-sensitive 5'-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent S6 kinase pathway.
Mario Pende,Mario Pende,Sung Hee Um,Virginie Mieulet,Melanie Sticker,Valerie Goss,Jürgen Mestan,Matthias Mueller,Stefano Fumagalli,Sara C. Kozma,George Thomas +10 more
TL;DR: It is shown that mice deficient for S 6K1 or S6K2 are born at the expected Mendelian ratio, and analysis of S6 phosphorylation in the cytoplasm and nucleoli of cells derived from the distinct S7K genotypes suggests that both kinases are required for full S6osphorylation but that S6k2 may be more prevalent in contributing to this response.
Journal ArticleDOI
Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development
Yann-Gaël Gangloff,Matthias Mueller,Stephen G. Dann,Petr Svoboda,Melanie Sticker,Jean-François Spetz,Sung Hee Um,Eric J. Brown,Silvia Cereghini,George Thomas,Sara C. Kozma,Sara C. Kozma +11 more
TL;DR: The mTOR gene is disrupted and embryonic development of homozygous mTOR − / − mice appears to be arrested at E5.5; such embryos are severely runted and display an aberrant developmental phenotype, consistent with the inability to establish embryonic stem cells from mTOR +/ − embryos.
Journal ArticleDOI
Corrigendum: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
Sung Hee Um,Francesca Frigerio,Mitsuhiro Watanabe,Frédéric Picard,Manel Joaquin,Melanie Sticker,Stefano Fumagalli,Peter R. Allegrini,Sara C. Kozma,Johan Auwerx,George Thomas +10 more
TL;DR: In this paper, the arrowhead from TSC to Rheb should be a horizontal bar (as from PKB to TSC), and the phosphorylation sites of IRS1 for human should be S312 and S636/639.