M
Melis Karaca
Researcher at Centre national de la recherche scientifique
Publications - 2
Citations - 507
Melis Karaca is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: P70-S6 Kinase 1 & Insulin receptor. The author has an hindex of 2, co-authored 2 publications receiving 478 citations.
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Journal ArticleDOI
mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes
Merav Fraenkel,Mali Ketzinel-Gilad,Yafa Ariav,Orit Pappo,Melis Karaca,Julien Castel,Marie-France Berthault,Christophe Magnan,Erol Cerasi,Nurit Kaiser,Gil Leibowitz +10 more
TL;DR: The essential role of mTOR/S6K1 in orchestrating β-cell adaptation to hyperglycemia in type 2 diabetes is emphasized and it is likely that treatments based on mTOR inhibition will cause exacerbation of diabetes.
Journal ArticleDOI
Physiological and Pharmacological Mechanisms through which the DPP-4 Inhibitor Sitagliptin Regulates Glycemia in Mice
Aurélie Waget,Cendrine Cabou,Myriam Masseboeuf,Pierre Cattan,Mattieu Armanet,Melis Karaca,Julien Castel,Céline Garret,Gaëlle Payros,Adriano Maida,Thierry Sulpice,Jens J. Holst,Daniel J. Drucker,Christophe Magnan,Rémy Burcelin +14 more
TL;DR: It is demonstrated that very low doses of oral sitagliptin improve glucose tolerance and plasma insulin levels with selective reduction of intestinal but not systemic DPP-4 activity.