M
Meng Wang
Publications - 14
Citations - 2658
Meng Wang is an academic researcher. The author has contributed to research in topics: Infectivity & Neutralization. The author has an hindex of 7, co-authored 13 publications receiving 1368 citations.
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Journal ArticleDOI
The Impact of Mutations in SARS-CoV-2 Spike on Viral Infectivity and Antigenicity.
Qianqian Li,Jiajing Wu,Jianhui Nie,Li Zhang,Huan Hao,Shuo Liu,Chenyan Zhao,Qi Zhang,Huan Liu,Lingling Nie,Haiyang Qin,Meng Wang,Qiong Lu,Xiaoyu Li,Qiyu Sun,Junkai Liu,Linqi Zhang,Xuguang Li,Weijin Huang,Youchun Wang +19 more
TL;DR: Most variants with amino acid change at receptor binding domain were less infectious but variants including A475V, L452R, V483A and F490L became resistant to some neutralizing antibodies, while deletion of both N331 and N343 glycosylation drastically reduced infectivity, revealing the importance of gly cosylation for viral infectivity.
Journal ArticleDOI
Establishment and validation of a pseudovirus neutralization assay for SARS-CoV-2.
Jianhui Nie,Qianqian Li,Jiajing Wu,Chenyan Zhao,Huan Hao,Huan Liu,Li Zhang,Lingling Nie,Haiyang Qin,Meng Wang,Qiong Lu,Xiaoyu Li,Qiyu Sun,Junkai Liu,Changfa Fan,Weijin Huang,Miao Xu,Youchun Wang +17 more
TL;DR: A robust pseudovirus-based neutralization assay for SARS-CoV-2 is established and is glad to share pseudoviruses and related protocols with the developers of vaccines or therapeutics to fight against this lethal virus.
Journal ArticleDOI
SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape.
Qianqian Li,Jianhui Nie,Jiajing Wu,Li Zhang,Ruxia Ding,Haixin Wang,Yue Zhang,Tao Li,Shuo Liu,Mengyi Zhang,Chenyan Zhao,Huan Liu,Lingling Nie,Haiyang Qin,Meng Wang,Qiong Lu,Xiaoyu Li,Junkai Liu,Haoyu Liang,Yi Shi,Yuelei Shen,Liangzhi Xie,Linqi Zhang,Xiaowang Qu,Wenbo Xu,Weijin Huang,Youchun Wang +26 more
TL;DR: In this article, experiments with 18 pseudotyped viruses showed that the 501Y.V2 variants do not confer increased infectivity in multiple cell types except for murine ACE2-overexpressing cells, where a substantial increase in infectivity was observed.
Journal ArticleDOI
Quantification of SARS-CoV-2 neutralizing antibody by a pseudotyped virus-based assay
Jianhui Nie,Qianqian Li,Jiajing Wu,Chenyan Zhao,Huan Hao,Huan Liu,Li Zhang,Lingling Nie,Haiyang Qin,Meng Wang,Qiong Lu,Xiaoyu Li,Qiyu Sun,Junkai Liu,Changfa Fan,Weijin Huang,Miao Xu,Youchun Wang +17 more
TL;DR: A pseudotyped virus-based neutralization assay against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in biosafety level 2 facilities to assess the level of neutralizing antibodies or molecular inhibitors in a sample.
Journal ArticleDOI
No Higher Infectivity But Immune Escape of SARS-CoV-2 501Y.V2 Variants
Qianqian Li,Nie Jianhui,Jiajing Wu,Li Zhang,Ruxia Ding,Haixin Wang,Yue Zhang,Tao Li,Shuo Liu,Mengyi Zhang,Chenyan Zhao,Huan Liu,Lingling Nie,Haiyang Qin,Meng Wang,Qiong Lu,Xiaoyu Li,Junkai Liu,Haoyu Liang,Yi Shi,Yuelei Shen,Liangzhi Xie,Linqi Zhang,Xiaowang Qu,Xiaowang Qu,Wenbo Xu,Weijin Huang,Youchun Wang +27 more
TL;DR: The data suggest that the enhancement of infectivity in mouse may lead to the spillover of 501Y.V2 to mouse, which may compromise the efficacy of monoclonal antibodies, convalescent sera and vaccines.