M
Mengying Wu
Researcher at Nanjing Medical University
Publications - 13
Citations - 146
Mengying Wu is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 7 publications receiving 40 citations.
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Journal ArticleDOI
Gasdermin E deficiency attenuates acute kidney injury by inhibiting pyroptosis and inflammation.
Weiwei Xia,Yuanyuan Li,Mengying Wu,Qianqian Jin,Qian Wang,Shuzhen Li,Songming Huang,Aihua Zhang,Yue Zhang,Zhanjun Jia +9 more
TL;DR: In this paper, the role of GSDME in renal cellular pyroptosis and acute kidney injury (AKI) pathogenesis was investigated using mice and human tubular epithelial cells.
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Antianemia Drug Roxadustat (FG-4592) Protects Against Doxorubicin-Induced Cardiotoxicity by Targeting Antiapoptotic and Antioxidative Pathways.
Long Guangfeng,Hongbing Chen,Mengying Wu,Yuanyuan Li,Ling Gao,Songming Huang,Yue Zhang,Zhanjun Jia,Weiwei Xia +8 more
TL;DR: FG-4592 could protect cardiomyocytes against DOX-induced apoptosis and ROS production in line with the upregulation of HIF-1α and its target genes of Bcl-2 and SOD2 and displayed anticancer property in cancer cells treated with or without DOX.
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Isoquercitrin Ameliorates Cisplatin-Induced Nephrotoxicity Via the Inhibition of Apoptosis, Inflammation, and Oxidative Stress.
Wang Hao,Weiwei Xia,Long Guangfeng,Zhiyin Pei,Yuanyuan Li,Mengying Wu,Wang Qian,Yue Zhang,Zhanjun Jia,Hongbing Chen +9 more
TL;DR: In vivo and in vitro findings demonstrated that IQC administration could significantly protect against cisplatin nephrotoxicity possibly through ameliorating apoptosis, inflammation and oxidative stress accompanied by cross talk with p-ERK.
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Celastrol attenuates ox-LDL-induced mesangial cell proliferation via suppressing NLRP3 inflammasome activation.
Zhenzhen Sun,Yuanyuan Li,Yun Qian,Mengying Wu,Songming Huang,Aihua Zhang,Yue Zhang,Zhanjun Jia +7 more
TL;DR: Celastrol potently blocked ox-LDL-induced MC proliferation, possibly by inhibiting NLRP3 inflammasome activation, and suggest that celastrol may be a potential drug for treating proliferative glomerular diseases related to obesity and lipid disorders.
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Inhibition of mitochondrial complex I activity attenuates neointimal hyperplasia by inhibiting smooth muscle cell proliferation and migration.
TL;DR: Findings indicated that ROT could block neointima formation by preventing the proliferation and migration of MOVA cells, possibly by inhibiting the mitochondrial respiratory chain activity, ATP production, AKT phosphorylation, MMP-9 activation, and ROS production.