Author
Merijn Schriks
Other affiliations: University of Amsterdam
Bio: Merijn Schriks is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Thyroid hormone receptor & Bioassay. The author has an hindex of 17, co-authored 32 publications receiving 1435 citations. Previous affiliations of Merijn Schriks include University of Amsterdam.
Topics: Thyroid hormone receptor, Bioassay, CALUX, European union, Thyroid
Papers
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TL;DR: The results show that for the majority of compounds a substantial margin of safety exists between the maximum concentration in surface water, groundwater and/or drinking water and the (provisional) guideline value.
367 citations
TL;DR: The chemical composition of the wastewater extracts used in a previous study was elucidated by means of LC-high-resolution Orbitrap MS/MS and to determine if the compounds quantified could account for the observed glucocorticoid responsive (GR) CALUX bioassay response.
Abstract: In the past two decades much research effort has focused on the occurrence, effects, and risks of estrogenic compounds. However, increasing emissions of new emerging compounds may also affect the action of hormonal pathways other than the estrogenic hormonal axis. Recently, a suite of novel CALUX bioassays has become available that enables looking further than estrogenic effects only. By employing these bioassays, we recently showed high glucocorticogenic activity in wastewaters collected at various sites in The Netherlands. However, since bioassays provide an integrated biological response, the identity of the responsible biological compounds remained unknown. Therefore, our current objective was to elucidate the chemical composition of the wastewater extracts used in our previous study by means of LC-high-resolution Orbitrap MS/MS and to determine if the compounds quantified could account for the observed glucocorticoid responsive (GR) CALUX bioassay response. The mass spectrometric analysis revealed th...
160 citations
Helmholtz Centre for Environmental Research - UFZ1, Swiss Federal Institute of Aquatic Science and Technology2, Norwegian Institute for Water Research3, Öko-Institut4, Stockholm University5, Spanish National Research Council6, Brunel University London7, Flemish Institute for Technological Research8, University of Novi Sad9, Utrecht University10, University of Birmingham11, University of Liverpool12, Nanjing University13, RWTH Aachen University14, Masaryk University15, Leibniz Association16, University of Gothenburg17, University of Bern18, State University of Campinas19
TL;DR: SOLUTIONS (2013 to 2018) is a European Union Seventh Framework Programme Project (EU-FP7) which aims to deliver a conceptual framework to support the evidence-based development of environmental policies with regard to water quality.
156 citations
TL;DR: A novel simplified protocol for effect-based monitoring of micropollutants in surface waters is presented and a comprehensive picture of the surface water status across Europe is drawn.
145 citations
TL;DR: The application of trigger values derived in the present study can help to judge measured agonistic hormonal activities in water samples using the CALUX bioassays and help to decide whether further examination of specific endocrine activity followed by a subsequent safety evaluation may be warranted.
108 citations
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TL;DR: The designations employed and the presentation of the material in this publication do not imply the expression of any opinion whatsoever on the part of UNEP or WHO concerning the legal status of any country, territory, city or area or of its authorities, or concerning the delimitation of its frontiers or boundaries.
1,192 citations
TL;DR: This review is a detailed review of published studies that have focused on the mechanistic basis of BPA action in diverse experimental models and an assessment of the strength of the evidence regarding the published BPA research.
850 citations
TL;DR: For some BFRs, the potency to induce AR antagonism, E2SULT inhibition, and TTR competition was higher than for natural ligands or clinical drugs used as positive controls, which support further investigation of the potential ED effects of these environmentally relevant B FRs in man and wildlife.
693 citations
TL;DR: In this paper, the energy efficiency of the forward osmosis (FO) process is analyzed and the potential use of low-cost energy sources is highlighted, emphasizing the importance of the structural parameter, reverse solute flux selectivity, and the constraints imposed by the permeability selectivity tradeoff.
686 citations
TL;DR: The routes by which these compounds enter groundwater, their toxicity and potential risks to drinking water and the environment are discussed, and challenges that need to be met are identified to minimise risk to Drinking water and ecosystems.
617 citations