Meron Roose-Girma

TL;DR: It is shown that cryopyrin-deficient macrophages cannot activate caspase-1 in response to Toll-like receptor agonists plus ATP, the latter activating the P2X7 receptor to decrease intracellular K+ levels.

TL;DR: Interestingly, cell death triggered by stimuli that engage caspase-1 was ablated in macrophages lacking either ASC or Ipaf, suggesting a coupling between the inflammatory and cell death pathways.

TL;DR: It is shown that macrophages from mice lacking absent in melanoma 2 (AIM2) cannot sense cytosolic double-stranded DNA and fail to trigger inflammasome assembly, and AIM2-deficient mice displayed increased susceptibility to F. tularensis infection compared with wild-type mice, confirming that A IM2 is essential for an effective innate immune response.

TL;DR: TACI may play an unexpected inhibitory role in B cell activation that helps maintain immunological homeostasis in mice that were deficient in TACI.

TL;DR: The discovery that Jagged antagonism relieves a blockade of cell-to-cell conversion unveils unexpected plasticity, and establishes a model for Notch regulation of transdifferentiation.