M
Merry Gunawan
Researcher at Newcastle University
Publications - 19
Citations - 1446
Merry Gunawan is an academic researcher from Newcastle University. The author has contributed to research in topics: Langerhans cell & CD14. The author has an hindex of 12, co-authored 19 publications receiving 1182 citations. Previous affiliations of Merry Gunawan include Nanyang Technological University & Agency for Science, Technology and Research.
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Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
Journal ArticleDOI
Human Dermal CD14+ Cells Are a Transient Population of Monocyte-Derived Macrophages
Naomi McGovern,Naomi McGovern,Andreas Schlitzer,Merry Gunawan,Laura Jardine,Amanda Shin,Elizabeth Poyner,Kile Green,Rachel E. Dickinson,Xiao-Nong Wang,Donovan Low,Katie Best,Samuel Covins,Paul Milne,Sarah Pagan,Khadija Aljefri,Martin Windebank,Diego Miranda-Saavedra,Anis Larbi,Pavandip Singh Wasan,Kaibo Duan,Michael Poidinger,Michael Poidinger,Venetia Bigley,Florent Ginhoux,Matthew Collin,Muzlifah Haniffa +26 more
TL;DR: The demonstration of monocyte-derived macrophages in the steady state in human tissue supports a conserved organization of human and mouse mononuclear phagocyte system.
Journal ArticleDOI
The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin
Merry Gunawan,Nandini Venkatesan,Jia Tong Loh,Jong Fu Wong,Heidi Berger,Wen Hao Neo,Liang Yao Jackson Li,Myint Khun La Win,Yin Hoe Yau,Tiannan Guo,Peter See,Sayuri Yamazaki,Keh Chuang Chin,Alexandre R. Gingras,Susana Geifman Shochat,Lai Guan Ng,Siu Kwan Sze,Florent Ginhoux,I-hsin Su +18 more
TL;DR: Ezh2 regulated the integrin signaling and adhesion dynamics of neutrophils and dendritic cells (DCs) and was abolished by targeted disruption of the interactions of Ezh2 with the cytoskeletal-reorganization effector Vav1.
Journal ArticleDOI
Human skin dendritic cells in health and disease.
TL;DR: Human skin dendritic cells (DCs) are heterogenous and functionally specialised, and dynamic changes occur in the composition of recruited ‘inflammatory’ DCs and resident DCs in inflamed skin.
Journal ArticleDOI
A Three-Dimensional Atlas of Human Dermal Leukocytes, Lymphatics, and Blood Vessels
Xiao-Nong Wang,Naomi McGovern,Merry Gunawan,C Richardson,Martin Windebank,Tee-Wei Siah,Hwee Ying Lim,Katja Fink,Jackson LiangYao Li,Lai G Ng,Florent Ginhoux,Veronique Angeli,Matthew Collin,Muzlifah Haniffa +13 more
TL;DR: Using four-channel whole-mount immunofluorescence staining of the human dermis, the three-dimensional distribution of CD31+ blood capillaries, LYVE-1+ lymphatics, discrete populations of CD11c+ myeloid DCs, FXIIIa+ Mφ, and lymphocytes is demonstrated.