Mette Boyd

TL;DR: It is shown that enhancers share properties with CpG-poor messenger RNA promoters but produce bidirectional, exosome-sensitive, relatively short unspliced RNAs, the generation of which is strongly related to enhancer activity.

TL;DR: High-throughput sequencing demonstrates that PROMPTs generally initiate in the antisense direction closely upstream of the transcription start sites (TSSs) of their associated genes.

TL;DR: A strategy to systematically categorize human RNAs by their sensitivity to the ribonucleolytic RNA exosome complex and by the nature of their transcription initiation is devised, which is surprisingly effective at correctly classifying annotated transcripts, including lncRNAs of known function.

TL;DR: CAGE-sequencing on descending colon biopsies of Crohn’s disease and ulcerative colitis patients is performed to map transcription start sites and enhancer activity for analysis of regulatory regions.

TL;DR: The ChIP-seq technique combines chromatin immunoprecipitation with next generation sequencing resulting in a high throughput experimental method of identifying direct targets of specific transcription factors, leading to the identification of the direct binding of CDX2 to several known and novel target genes in the intestinal cell.