Author
Mhairi Simpson
Other affiliations: National Health Service, Wishaw General Hospital
Bio: Mhairi Simpson is an academic researcher from NHS Lanarkshire. The author has contributed to research in topics: Needs assessment & Health care. The author has an hindex of 8, co-authored 10 publications receiving 313 citations. Previous affiliations of Mhairi Simpson include National Health Service & Wishaw General Hospital.
Papers
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TL;DR: Investing time to sensitively inquire about the supportive care needs of this patient population is key, whilst evaluating and re-shaping clinical interactions based on patients' priorities is equally essential.
112 citations
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TL;DR: The use of patient reported outcome measures as a clinical intervention tool may be viewed as a means of identifying and managing unmet needs in this patient population.
110 citations
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TL;DR: Despite a host of additional needs experienced by women with cervical cancer, a predominant focus on sexuality/intimacy and information seeking issues is noted, preventing conclusions as to how these needs evolve over time from diagnosis to treatment and subsequently to survivorship from being drawn.
88 citations
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University of Turku1, Imperial College Healthcare2, Glasgow Caledonian University3, Uppsala University4, Erasmus University Rotterdam5, National and Kapodistrian University of Athens6, Karolinska Institutet7, First Faculty of Medicine, Charles University in Prague8, University of Lausanne9, University of Manchester10, Karlstad University11, NHS Lanarkshire12, The Royal Marsden NHS Foundation Trust13, Royal College of Nursing14
TL;DR: This is the first review to synthesise evidence from intervention studies across the entire cancer spectrum and provides new insights into the nature of the contribution that cancer nurses have made to evidence-based innovations, as well as highlighting areas in which cancer nursing trials can be developed in the future.
75 citations
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TL;DR: Nurse-led, PROMs-driven needs assessments with patients with CRC appear to be feasible and acceptable in clinical practice, possibly associated with a sizeable reduction in the frequency of unmet needs, and smaller decreases in physical/daily living and psychosocial needs in the immediate post-chemotherapy period.
24 citations
Cited by
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TL;DR: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs?
Abstract: Definition: To what extent does the study allow us to draw conclusions about a causal effect between two or more constructs? Issues: Selection, maturation, history, mortality, testing, regression towrd the mean, selection by maturation, treatment by mortality, treatment by testing, measured treatment variables Increase: Eliminate the threats, above all do experimental manipulations, random assignment, and counterbalancing.
2,006 citations
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01 Apr 2008-Centre for Health Research; Faculty of Health; Institute of Health and Biomedical Innovation
TL;DR: In this article, a study aimed to determine the prevalence and correlates of unmet needs within a population of gynaecological cancer survivors, and identified subgroups with higher need for support.
Abstract: After treatment completion, gynaecological cancer survivors may face long-term challenges and late effects, specific to this disease. Available research on supportive care needs of women with gynaecological cancer is limited. This study aimed to determine the prevalence and correlates of unmet needs within a population of gynaecological cancer survivors. Eight-hundred and two women participated in a population-based mail survey in 2004 (56% response rate). The questionnaire included a validated instrument to assess 45 need items across multiple supportive care domains, and a range of measures to evaluate related correlates consistent with a social-ecological perspective. Forty-three percent of respondents reported having at least one moderate or high level unmet need. The five highest included needing help with fear about the cancer spreading (17%), concerns about the worries of those close to them (15%), uncertainty about the future (14%), lack of energy/tiredness (14%), and not being able to do things they used to do (14%). Subgroups of women with higher odds of reporting 'some' unmet needs across multiple supportive care domains include those who, are not in remission, live with lymphoedema or are unable to work due to illness. Odds were also higher for women who had undergone more recent treatment, and who lived in rural or remote locations. Further assistance with the top specific concerns of gynaecological cancer survivors is recommended. Identified subgroups with higher needs are important targets for support.
133 citations
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TL;DR: New knowledge on CSCs and CCSCs is updated, potential stem cell markers and functional assays for identifying CCSC’s are reviewed, and the potential of targetingCCSCs in the treatment of cervical carcinoma is described.
Abstract: Accumulating evidence has shown that cancer stem cells (CSCs) have a tumour-initiating capacity and play crucial roles in tumour metastasis, relapse and chemo/radio-resistance. As tumour propagation initiators, CSCs are considered to be promising targets for obtaining a better therapeutic outcome. Cervical carcinoma is the most common gynaecological malignancy and has a high cancer mortality rate among females. As a result, the investigation of cervical cancer stem cells (CCSCs) is of great value. However, the numbers of cancer cells and corresponding CSCs in malignancy are dynamically balanced, and CSCs may reside in the CSC niche, about which little is known to date. Therefore, due to their complicated molecular phenotypes and biological behaviours, it remains challenging to obtain "purified" CSCs and continuously culture CSCs for further in vitro studies without the cells losing their stem properties. At present, CSC-related markers and functional assays are used to purify, identify and therapeutically target CSCs both in vitro and in vivo. Nevertheless, CSC-related markers are not universal to all tumour types, although some markers may be valid in multiple tumour types. Additionally, functional identifications based on CSC-specific properties are usually limited in in vivo studies. Furthermore, an optimal method for identifying potential CCSCs in CCSC studies has not been previously published, and these techniques are currently of great importance. This article updates our knowledge on CSCs and CCSCs, reviews potential stem cell markers and functional assays for identifying CCSCs, and describes the potential of targeting CCSCs in the treatment of cervical carcinoma.
114 citations
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TL;DR: Investing time to sensitively inquire about the supportive care needs of this patient population is key, whilst evaluating and re-shaping clinical interactions based on patients' priorities is equally essential.
112 citations
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TL;DR: The use of patient reported outcome measures as a clinical intervention tool may be viewed as a means of identifying and managing unmet needs in this patient population.
110 citations