M
Michael A. Beckett
Researcher at University of Chicago
Publications - 90
Citations - 13124
Michael A. Beckett is an academic researcher from University of Chicago. The author has contributed to research in topics: Radioresistance & Radiation therapy. The author has an hindex of 46, co-authored 88 publications receiving 11857 citations. Previous affiliations of Michael A. Beckett include Harvard University.
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Journal ArticleDOI
Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice
Liufu Deng,Hua Liang,Byron Burnette,Michael A. Beckett,Thomas E. Darga,Ralph R. Weichselbaum,Yang Xin Fu +6 more
TL;DR: Evidence is provided for a close interaction between IR, T cells, and the PD-L1/PD-1 axis and a basis for the rational design of combination therapy with immune modulators and radiotherapy is established.
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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Liufu Deng,Hua Liang,Meng Xu,Xuanming Yang,Byron Burnette,Ainhoa Arina,Xiao Dong Li,Helena J. Mauceri,Michael A. Beckett,Thomas E. Darga,Xiaona Huang,Thomas F. Gajewski,Zhijian J. Chen,Yang Xin Fu,Ralph R. Weichselbaum +14 more
TL;DR: Radiation-mediated antitumor immunity in immunogenic tumors requires a functional cytosolic DNA-sensing pathway and suggests that cGAMP treatment might provide a new strategy to improve radiotherapy.
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Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment
Youjin Lee,Sogyong L. Auh,Yugang Wang,Byron Burnette,Yang Wang,Yuru Meng,Michael A. Beckett,Rohit Sharma,Robert K. Chin,Tony Tu,Ralph R. Weichselbaum,Yang Xin Fu +11 more
TL;DR: It is reported that reduction of tumor burden after ablative RT depends largely on T-cell responses, and the need for new strategies that not only reduce tumor burden but also enhance the role of antitumor immunity is emphasized.
Journal Article
Blockade of the Vascular Endothelial Growth Factor Stress Response Increases the Antitumor Effects of Ionizing Radiation
David H. Gorski,Michael A. Beckett,Nora Jaskowiak,Douglas P. Calvin,Helena J. Mauceri,Rabih M. Salloum,Saraswathy Seetharam,Ann Koons,Danielle M. Hari,Donald Kufe,Ralph R. Weichselbaum +10 more
TL;DR: It is reported that VEGF expression is induced in Lewis lung carcinomas (LLCs) both in vitro and in vivo after exposure to ionizing radiation (IR) and in human tumor cell lines (Seg-1 esophageal adenocarcinoma, SQ20B squamous cell carcinoma, T98 and U87 glioblastomas, and U1 melanoma) in vitro.
Journal Article
Tumorigenic Keratinocyte Lines Requiring Anchorage and Fibroblast Support Cultured from Human Squamous Cell Carcinomas
TL;DR: It is demonstrated that SCC's often grow as established lines in culture, but they frequently possess in vitro growth requirements similar to those of normal keratinocytes.