Michael B. Sporn

TL;DR: A procedure has been developed for the iodination of human transforming growth factor-beta (TGF-beta) with full retention of biological activity using the iodinated peptide, saturable receptors have been found on normal rat kidney fibroblasts, a cell line that will grow in soft agar in the presence of TGFs but not in their absence.

TL;DR: Experiments in which wound healing chambers were implanted subcutaneously in the backs of rats, these bovine transforming growth factors accelerated the accumulation of total protein, collagen, and DNA in treated chambers, showing an effect of an isolated transforming growth factor in vivo.

TL;DR: It is demonstrated that the expression of each of the two forms of TGF‐β is independently regulated, and sensitive and specific immunological assays for TGF •β1 and •β2 in complex biological fluids are described.

TL;DR: The properties of these intracellular polypeptides from both virally and chemically transformed cells are similar to those described for the Sarcoma growth factors previously isolated from the conditioned medium of sarcoma virus-transformed mouse 3T3 cells, suggesting the definition of a class of transforming growth factors common to tumor cells of different origins.

TL;DR: A rat model of bleomycin-induced pulmonary inflammation and fibrosis was used to examine the relationship between collagen synthesis and transforming growth factor beta (TGF-beta) production, and cellular distribution.