M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Journal ArticleDOI
Induction of transforming growth factor-α in activated human alveolar macrophages
David K. Madtes,Elaine W. Raines,Kjell S. Sakariassen,Richard K. Assoian,Michael B. Sporn,Graeme I. Bell,Russell Ross +6 more
TL;DR: It is demonstrated that activated human alveolar macrophages express the gene for transforming growth factor-α (TGF-α) in an inducible manner and secrete a factor into the culture medium that is functionally and immunologically identical to TGF- α.
Journal ArticleDOI
Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide
Rajesh K. Thimmulappa,Catherine Scollick,Kassim Traore,Melinda S. Yates,Michael A. Trush,Karen T. Liby,Michael B. Sporn,Masayuki Yamamoto,Masayuki Yamamoto,Thomas W. Kensler,Shyam Biswal +10 more
TL;DR: The results suggest that Nrf2 is associated with oxidative regulation of LPS induced innate immune response in neutrophils and Activation of NRF2-dependent compensatory antioxidative pathways by CDDO-Im protects from L PS induced inflammatory response and mortality.
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An Inducible Pathway for Degradation of FLIP Protein Sensitizes Tumor Cells to TRAIL-induced Apoptosis *
TL;DR: It is demonstrated here that a variety of natural and synthetic ligands of peroxisome proliferator-activated receptor-γ (PPARγ) sensitize tumor but not normal cells to apoptosis induction by TRAIL, suggesting the existence of a pharmacologically regulated novel target of this class of drugs that controls FLIP protein turnover.
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Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis.
TL;DR: The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis.
Journal Article
A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity
Nanjoo Suh,Yongping Wang,Tadashi Honda,Gordon W. Gribble,Ethan Dmitrovsky,William F. Hickey,Robert A. Maue,Andrew E. Place,Donna M. Porter,Michael J. Spinella,Charlotte R. Williams,Gengfei Wu,Andrew J. Dannenberg,Kathleen C. Flanders,John J. Letterio,David J. Mangelsdorf,Carl Nathan,Lananh Nguyen,Weston Porter,Renee F. Ren,Anita B. Roberts,Nanette S. Roche,Kotha Subbaramaiah,Michael B. Sporn +23 more
TL;DR: The results suggest that CDDO needs further study in vivo, for either chemoprevention or chemotherapy of malignancy as well as for neuroprotection.