M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Transforming growth factor-β controls receptor levels for epidermal growth factor in NRK fibroblasts
TL;DR: A mechanism of growth control is described in which bioactive peptides act coordinately through a regulatory effect on the number of cell-surface receptors through a selective synthetic mechanism underlies TGF-beta action.
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Hypoxia upregulates the synthesis of tgf-β1 by human dermal fibroblasts
Vincent Falanga,Su Wen Qian,David Danielpour,Matthew H. Katz,Anita B. Roberts,Michael B. Sporn +5 more
TL;DR: It is concluded that low oxygen tension upregulates the synthesis of TGF-β1 by human dermal fibroblasts, and leads to increased secretion of this peptide.
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Complementary Deoxyribonucleic Acid Cloning of a Messenger Ribonucleic Acid Encoding Transforming Growth Factor β 4 from Chicken Embryo Chondrocytes
TL;DR: Using a human transforming growth factor beta 1 (TGF beta) cDNA probe, an RNA species migrating at about 1.7 kilobases in cultured primary chicken embryo chondrocytes is detected that is distinct from chicken TGF beta 1.
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Transactivation of the transforming growth factor beta 1 (TGF-beta 1) gene by human T lymphotropic virus type 1 tax: a potential mechanism for the increased production of TGF-beta 1 in adult T cell leukemia.
Seong-Jin Kim,John H. Kehrl,Jack D. Burton,Craig L. Tendler,Kuan-Teh Jeang,David Danielpour,C. Thevenin,Kyung Young Kim,Michael B. Sporn,Anita B. Roberts +9 more
TL;DR: A role for Tax in the upregulation of TGF-beta 1 in HTLV-I-infected cells is suggested, which is similar to that suggested for T lymphotropic virus type 1.
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Colocalization of TGF-beta 1 and collagen I and III, fibronectin and glycosaminoglycans during lung branching morphogenesis
TL;DR: The results indicate colocalization of TGF-beta 1 expression and that of matrix proteins in the developing lung when branching morphogenesis (cleft formation) and tissue stabilization occur, and suggests a direct participation of the growth factor in the development of the basic architecture of the lung.