Michael B. Sporn

TL;DR: CDDO-EA and CDDO-TFEA upregulated Nrf2/ARE induced genes in the brain and peripheral tissues, reduced oxidative stress, improved motor impairment and increased longevity, which shows great promise for the treatment of HD.

TL;DR: Investigation of the Biological activity of seven analogues of natural vitamin A ester (β-retinyl acetate) and vitamin A acid and found that several vitamin A analogues with alterations in the ring, including a shift of the 5,6-double bond of the cyclohexene ring to the 4,5-position and replacement of the cycle with substituted aromatic and cyclopentene rings, have substantial activity in the skin and tracheobronchial assays.

TL;DR: The first evidence that TGF-β is present in a healing wound is presented and it is suggested that it may be an intrinsic mediator of the healing process.

TL;DR: Results suggest that CDDO functions by activating the intrinsic pathway of apoptosis and initiates caspase-dependent and independent cell death in intact cells, and the direct modulation of mitochondrial-mediated, caspasing-independent apoptosis by CDDO may be advantageous for overcoming chemoresistance in AML.

TL;DR: Structure-activity relationships are summarized for 87 retinoids, using reversal of keratinization in the hamster tracheal organ culture system to measure biological activity.