M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Journal ArticleDOI
Antioxidant vitamins, cancer, and cardiovascular disease
E R Greenberg,Michael B. Sporn +1 more
TL;DR: These observations were used to support the theory that epidemics result from infective spores carried by the wind from decaying organic matter; the netting and screens were believed to add much to the security of the occupant of a chamber, in even the most unsound places.
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Structure and properties of the cellular receptor for transforming growth factor type beta.
TL;DR: Swiss 3T3 cells respond to picomolar concentrations of type beta transforming growth factor with a dose-dependent increase in the formation of colonies in soft agar, a decrease in the growth of cells in monolayer culture, and changes in morphology, indicating that these cells have functional TGF-beta receptors able to mediate a biological response.
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Triterpenoid CDDO–methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease
Magali Dumont,Elizabeth Wille,Noel Y. Calingasan,Davide Tampellini,Charlotte R. Williams,Gunnar K. Gouras,Karen T. Liby,Michael B. Sporn,M. Flint Beal,Michael T. Lin +9 more
TL;DR: The effect of the triterpenoid, CDDO‐MA, significantly improved spatial memory retention and reduced plaque burden, Aβ42 levels, microgliosis, and oxidative stress in Tg19959 mice.
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Recombinant TGF-β1 is Synthesized as a Two-Component Latent Complex that Shares Some Structural Features with the Native Platelet Latent TGF-β1 Complex
Lalage M. Wakefield,Diane M. Smith,Susan D. Broz,Mark L. Jackson,Arthur D. Levinson,Michael B. Sporn +5 more
TL;DR: Investigation of the entire coding region of the human transforming growth factor β1 (TGF-β1) precursor cDNA has been stably expressed in a human renal carcinoma cell line indicates that the recombinant latent TGF- β1 is a 100-kDa complex in which active 25-k da TGF -β1 is noncovalently associated with the remaining 75 kDa of the processed precursor.