M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
Papers
More filters
Journal ArticleDOI
The isolation of cell nuclei from rat brain
TL;DR: A method for preparing highly pure cell nuclei from adult rat brain, using both differential and isopycnic centrifugation in sucrose media, is described and results of application of the technique to isolation of adult rat liver nuclei are reported.
Journal ArticleDOI
Binding Affinity of Transforming Growth Factor-β for Its Type II Receptor Is Determined by the C-terminal Region of the Molecule
Su Wen Qian,James K. Burmester,Monica L.-S. Tsang,James A. Weatherbee,Andrew P. Hinck,Dennis J. Ohlsen,Michael B. Sporn,Anita B. Roberts +7 more
TL;DR: Observations clearly indicate that the domain in TGF-β1 responsible for its high affinity binding to TβRII, both the soluble and membrane-bound forms, is located at C terminus of the molecule.
Journal ArticleDOI
Complementary Deoxyribonucleic Acid Cloning of an mRNA Encoding Transforming Growth Factor- β2 from Chicken Embryo Chondrocytes
TL;DR: Using a simian transforming growth factor-beta 2 (TGF- Beta 2) cDNA probe, isolated chicken cDNA clones for TGF- beta 2 from a chicken embryo chondrocyte cDNA library is isolated and the predicted precursor protein is 412 amino acids long, two amino acids shorter than the human form.
Journal ArticleDOI
Nucleotide synthesis. IV. Phosphorylated 3'-amino-3'-deoxythymidine and 5'-amino-5'-deoxythymidine and derivatives
Journal ArticleDOI
Secretion and transcriptional regulation of transforming growth factor-beta 3 during myogenesis.
TL;DR: The high level of TGF-beta 3 mRNA expression in muscle cells appears to be dependent on multiple regulatory events during different stages of myogenesis, including fusion of C2C12 cells into myotubes.