M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Patent
Synthetic triterpenoids and methods of use in the treatment of disease
TL;DR: In this paper, methods for treating and preventing renal/kidney disease, insulin resistance/diabetes, fatty liver disease, and/or endothelial dysfunction/cardiovascular disease using synthetic triterpenoids, optionally in combination with a second treatment or prophylaxis.
Journal ArticleDOI
Identification of a structural domain that distinguishes the actions of the type 1 and 2 isoforms of transforming growth factor beta on endothelial cells
Su Wen Qian,James K. Burmester,June R. Merwin,Joseph A. Madri,Michael B. Sporn,Anita B. Roberts +5 more
TL;DR: The results identify the sequence between amino acids 40-82 as an important region within TGF-beta that functions to specify a T GF-beta 1- or TGF -beta 2-like activity.
Book ChapterDOI
Anti-angiogenic Activity of a Novel Class of Chemopreventive Compounds: Oleanic Acid Terpenoids
Ilaria Sogno,Nicola Vannini,Girieca Lorusso,Rosaria Cammarota,Douglas M. Noonan,Luca Generoso,Michael B. Sporn,Andriana Albini +7 more
TL;DR: The particularly potent anti-angiogenic activity seen in vivo suggest that CDDO-Me may be interacting with an important network of molecular and cellular targets, on endothelial cells, and could be employed for ‘angioprevention’.
Journal ArticleDOI
Peroxisome Proliferator-Activated Receptor-γ-Independent Repression of Collagenase Gene Expression by 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic Acid and Prostaglandin 15-Deoxy-Δ(12,14) J2: A Role for Smad Signaling
Kimberlee S. Mix,Charles I. Coon,Evan D. Rosen,Nanjoo Suh,Michael B. Sporn,Constance E. Brinckerhoff +5 more
TL;DR: It is concluded that CDDO represses MMP gene expression through a novel PPAR-gamma-independent mechanism that requires Smad signaling, and the effect of CDDO on the transforming growth factor-beta (TGF-beta) signaling pathway.
Journal ArticleDOI
Design and synthesis of tricyclic compounds with enone functionalities in rings A and C: a novel class of highly active inhibitors of nitric oxide production in mouse macrophages.
Frank G. Favaloro,Tadashi Honda,Yukiko Honda,Gordon W. Gribble,Nanjoo Suh,Renee Risingsong,Michael B. Sporn +6 more
TL;DR: Ten novel tricyclic compounds with enone functionalities in rings A and C, which were designed on the basis of the structure of a synthetic triterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid, have been synthesized and shows high inhibitory activity against production of nitric oxide induced by interferon-gamma.