M
Michael B. Sporn
Researcher at Dartmouth College
Publications - 561
Citations - 96644
Michael B. Sporn is an academic researcher from Dartmouth College. The author has contributed to research in topics: Transforming growth factor & Transforming growth factor beta. The author has an hindex of 157, co-authored 559 publications receiving 94605 citations. Previous affiliations of Michael B. Sporn include Cornell University & Reata Pharmaceuticals.
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Purification of T antigen from nuclei of simian virus 40-induced hamster tumors.
TL;DR: The extensive purification of the simian virus 40 (SV40) T antigen is reported from nuclei of transplanted, virus-free hamster tumors originally induced by SV40 virus to lead to further definition of its role.
Journal Article
Transforming growth factor-beta s in mammary tumorigenesis: promoters or antipromoters?
Lalage M. Wakefield,John J. Letterio,Andrew G. Geiser,Kathleen C. Flanders,Joyce A. O'Shaughnessy,Anita B. Roberts,Michael B. Sporn +6 more
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Rexinoids for Prevention and Treatment of Cancer: Opportunities and Challenges
Karen T. Liby,Michael B. Sporn +1 more
TL;DR: 4 rexinoids are reviewed for their ability to suppress proliferation of cancer cells, to inhibit activation of inflammatory cells of the tumor microenvironment, and to prevent carcinogenesis in animal models relevant to human disease.
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New Synthetic Triterpenoids: Potent Agents for Prevention and Treatment of Tissue Injury Caused by Inflammatory and Oxidative Stress
Michael B. Sporn,Karen T. Liby,Mark M. Yore,Liangfeng Fu,Justin M. Lopchuk,Gordon W. Gribble +5 more
TL;DR: A review of the original rationale for the development and the chemistry of a series of new synthetic oleanane triterpenoids (SO) based on oleanolic acid as a starting material is given in this paper.
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Inhibition of transforming growth factor-induced cell growth in soft agar by oxidized polyamines
Charles A. Frolik,Peter P. Roller,James L. Cone,Linda L. Dart,Diane M. Smith,Michael B. Sporn +5 more
TL;DR: It is concluded that an oxidation product of spermine is responsible for the previously reported inhibition of colony growth in soft agar following treatment of normal fibroblasts with transforming growth factors.