Michael B. Sporn

TL;DR: Urinary bladders from Fischer rats organ cultured in a chemically defined medium, Ham's F12, underwent transitional cell hyperplasia which persisted for the duration of the culture period (10 days), and the hyperplastic response in the transitional epithelium was significantly inhibited by hydrocortisone.

TL;DR: In this paper, the HO-1-DsRed-knock-in reporter mouse was used to study the role of the DsRed gene in the HO1-DsRed fusion protein in peritoneal macrophages.

TL;DR: The conventional clinical approach with most epithelial cancer has been to wait until the patient has invasive disease and then treat this disease with cytotoxic chemotherapy, surgery, or radiation; none of these modalities has been uniquely successful for the treatment of all types of epithelialcancer.

TL;DR: Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided in this paper, where a method for producing a cell such as a stem or pro-germanic cell with induced gene expression by contacting a stem/progenitor cell with an effective amount of a synthetic triterpoid to induce the expression of one or more of SOX9 (Sex determining region Y-box 9), COL2A1 (Type II Collagen (alpha1)), TGF-βI, TGF