M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Complement genes contribute sex-biased vulnerability in diverse disorders
Nolan Kamitaki,Nolan Kamitaki,Aswin Sekar,Aswin Sekar,Robert E. Handsaker,Robert E. Handsaker,Heather de Rivera,Heather de Rivera,Katherine Tooley,Katherine Tooley,David L. Morris,Kimberly E. Taylor,Christopher W. Whelan,Christopher W. Whelan,Philip Tombleson,Loes M. Olde Loohuis,Loes M. Olde Loohuis,Michael Boehnke,Robert P. Kimberly,Kenneth M. Kaufman,John B. Harley,Carl D. Langefeld,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman,Michele T. Pato,Carlos N. Pato,Roel A. Ophoff,Roel A. Ophoff,Robert R. Graham,Lindsey A. Criswell,Timothy J. Vyse,Steven A. McCarroll,Steven A. McCarroll +33 more
TL;DR: Sexual dimorphism in genetic vulnerability to schizophrenia, systemic lupus erythematosus and Sjögren’s syndrome is linked to differential protein abundance from alleles of complement component 4, which implicate the complement system as a source of sexual dimorphisms in vulnerability to diverse illnesses.
Journal ArticleDOI
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity
Christina L. Usher,Robert E. Handsaker,Tõnu Esko,Marcus A. Tuke,Michael N. Weedon,Alex Hastie,Han Cao,Jennifer E. Moon,Seva Kashin,Christian Fuchsberger,Andres Metspalu,Carlos N. Pato,Michele T. Pato,Mark I. McCarthy,Michael Boehnke,David Altshuler,Timothy M. Frayling,Joel N. Hirschhorn,Steven A. McCarroll +18 more
TL;DR: It is found that the AMY1 copy number in an individual's genome is generally even (rather than odd) and partially correlates with nearby SNPs, which do not associate with body mass index (BMI).
Journal ArticleDOI
Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.
Cristen J. Willer,Lori L. Bonnycastle,Karen N. Conneely,William L. Duren,Anne U. Jackson,Laura J. Scott,Narisu Narisu,Peter S. Chines,Andrew D. Skol,Heather M. Stringham,John Petrie,Michael R. Erdos,Amy J. Swift,Sareena T. Enloe,Andrew G. Sprau,Eboni Smith,Maurine Tong,Kimberly F. Doheny,Elizabeth W. Pugh,Richard M. Watanabe,Thomas A. Buchanan,Timo T. Valle,Richard N. Bergman,Jaakko Tuomilehto,Jaakko Tuomilehto,Karen L. Mohlke,Francis S. Collins,Michael Boehnke +27 more
TL;DR: The replication of 12 SNPs of 114 tested was significantly greater than expected by chance under the null hypothesis of no association, and SNPs from genes that had three or more previous reports of association were significantly more likely to be replicated in this sample.
Journal Article
Limits of resolution of genetic linkage studies: implications for the positional cloning of human disease genes
TL;DR: The results provide explicit sample-size guidelines for future positional cloning studies of Mendelian diseases and make possible a more objective evaluation of whether a proposed positional cloning study is likely to be successful.
Journal Article
Mapping of a gene for autosomal dominant juvenile-onset open-angle glaucoma to chromosome Iq.
Julia E. Richards,Paul R. Lichter,Michael Boehnke,J. L. A. Uro,D. Torrez,Deborah J. Wong,A. T. Johnson +6 more
TL;DR: A large Caucasian family is presented, in which a juvenile-onset form of open-angle glaucoma is transmitted in an autosomal dominant fashion and analysis of recombinant haplotypes suggests a total inclusion region of about 14 cM between markers D1S194 andD1S218 at 1q21-q31.