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Michael Boehnke

Researcher at University of Michigan

Publications -  540
Citations -  155551

Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.

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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease

Robert A. Scott, +162 more
TL;DR: A low-frequency missense variant in the gene encoding glucagon-like peptide-1 receptor, the target of GLP1R agonists, was associated with lower fasting glucose and T2D risk, consistent with GLP 1R agonist therapies, and provided evidence that GLP2D agonists are not likely to be associated with an unacceptable increase in cardiovascular risk.
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Autosomal Dominant Diabetes Arising From a Wolfram Syndrome 1 Mutation

Lori L. Bonnycastle, +18 more
- 01 Nov 2013 - 
TL;DR: A novel nonsynonymous variant (p.Trp314Arg) in the Wolfram syndrome 1 (WFS1) gene is uncovered that segregates completely with the diabetic phenotype and represents the first compelling report of a mutation in WFS1 associated with dominantly inherited nonsyndromic adult-onset diabetes.

Defining the role of common variation in the genomic and biological architecture of adult human height

Andrew R. Wood, +444 more
TL;DR: The results indicate a genetic architecture for human height that is characterized by a very large but finite number of causal variants, including mTOR, osteoglycin and binding of hyaluronic acid.
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Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes

Viktoria Gusarova, +91 more
- 13 Jun 2018 - 
TL;DR: It is found that predicted loss-of-function variants in ANGPTL4 are associated with glucose homeostasis and reduced risk of type 2 diabetes and that Angptl4−/− mice on a high-fat diet show improved insulin sensitivity.
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A genome-wide association study of IVGTT-based measures of first-phase insulin secretion refines the underlying physiology of type 2 diabetes variants

Andrew R. Wood, +55 more
- 01 Aug 2017 - 
TL;DR: The largest genome-wide association study of first-phase insulin secretion, as measured by intravenous glucose tolerance tests, using up to 5,567 individuals without diabetes from 10 studies is performed, providing further insight into the mechanisms by which common genetic variation influences type 2 diabetes risk and glycemic traits.