M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Experimental design and error detection for polyploid radiation hybrid mapping.
TL;DR: It is found that in general, combinations of ploidy and chromosome-specific retention rates that lead to a per-hybrid retention rate of approximately 50% result in the greatest power to order markers, and analyzing polyploid radiation hybrids as if they were haploid does not compromise the ability to order marker but does result in less accurate intermarker distance estimates.
Journal Article
Fine-structure genetic mapping of human chromosomes using the polymerase chain reaction on single sperm: experimental design considerations.
TL;DR: Sperm typing will be an efficient method for generating fine-structure human genetic maps and Sequential analysis of trios of loci by sperm typing will provide a very accurate means of ordering any number of tightly linked loci.
Journal ArticleDOI
Novel association of TM6SF2 rs58542926 genotype with increased serum tyrosine levels and decreased apoB-100 particles in Finns
Daniel Seung Kim,Anne U. Jackson,Yatong K. Li,Heather M. Stringham,Johanna Kuusisto,Antti J. Kangas,Pasi Soininen,Mika Ala-Korpela,Charles F. Burant,Veikko Salomaa,Michael Boehnke,Markku Laakso,Elizabeth K. Speliotes +12 more
TL;DR: A glutamate-to-lysine variant (rs58542926-T) in transmembrane 6 superfamily member 2 (TM6SF2) is associated with increased fatty liver disease and diabetes in conjunction with decreased cardiovascular disease risk as discussed by the authors.
Journal ArticleDOI
New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders
Evangelos Evangelou,Evangelos Evangelou,He Gao,Congying Chu,Georgios Ntritsos,Paul Blakeley,Andrew R. Butts,Raha Pazoki,Hideaki Suzuki,Hideaki Suzuki,Fotios Koskeridis,Andrianos M. Yiorkas,Andrianos M. Yiorkas,Ibrahim Karaman,Joshua Elliott,Qiang Luo,Qiang Luo,Stefanie Aeschbacher,Traci M. Bartz,Sebastian E. Baumeister,Sebastian E. Baumeister,Peter S. Braund,Peter S. Braund,Michael R. Brown,Jennifer A. Brody,Toni-Kim Clarke,Niki Dimou,Jessica D. Faul,Georg Homuth,Anne U. Jackson,Katherine A. Kentistou,Peter K. Joshi,Rozenn N. Lemaitre,Penelope A. Lind,Leo-Pekka Lyytikäinen,Massimo Mangino,Massimo Mangino,Yuri Milaneschi,Christopher P. Nelson,Christopher P. Nelson,Ilja M. Nolte,Mia-Maria Perälä,Ozren Polasek,David J. Porteous,Scott M. Ratliff,Jennifer A. Smith,Alena Stančáková,Alexander Teumer,Samuli Tuominen,Sébastien Thériault,Sébastien Thériault,Jagadish Vangipurapu,John Whitfield,Alexis C. Wood,Jie Yao,Bing Yu,Wei Zhao,Dan E. Arking,Juha Auvinen,Chunyu Liu,Minna Männikkö,Lorenz Risch,Jerome I. Rotter,Harold Snieder,Juha Veijola,Alexandra I. F. Blakemore,Alexandra I. F. Blakemore,Michael Boehnke,Harry Campbell,David Conen,Johan G. Eriksson,Johan G. Eriksson,Hans J. Grabe,Hans J. Grabe,Xiuqing Guo,Pim van der Harst,Catharina A. Hartman,Caroline Hayward,Andrew C. Heath,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Kähönen,Sharon L.R. Kardia,Michael Kühne,Johanna Kuusisto,Markku Laakso,Jari Lahti,Terho Lehtimäki,Andrew M. McIntosh,Karen L. Mohlke,Alanna C. Morrison,Nicholas G. Martin,Albertine J. Oldehinkel,Brenda W.J.H. Penninx,Bruce M. Psaty,Bruce M. Psaty,Olli T. Raitakari,Igor Rudan,Nilesh J. Samani,Nilesh J. Samani,Laura J. Scott,Tim D. Spector,Niek Verweij,David R. Weir,James F. Wilson,Daniel Levy,Ioanna Tzoulaki,Jimmy D. Bell,Paul M. Matthews,Adrian Rothenfluh,Sylvane Desrivières,Gunter Schumann,Gunter Schumann,Paul Elliott +114 more
TL;DR: This article conducted a meta-analysis of genome-wide association studies of alcohol consumption from the UK Biobank, the Alcohol Genome Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake.
Posted ContentDOI
Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans
Jedidiah Carlson,Laura J. Scott,Adam E. Locke,Matthew Flickinger,Shawn Levy,Richard M. Myers,Michael Boehnke,Hyun Min Kang,Jun Li,Sebastian Zöllner +9 more
TL;DR: This work uses ∼36 million singleton variants from 3,560 whole-genome sequences to infer fine-scale patterns of mutation rate heterogeneity and provides the most refined portrait to date of the factors contributing to genome-wide variability of the human germline mutation rate.