M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal Article
A radiation hybrid map of the distal short arm of human chromosome 11, containing the Beckwith-Wiedemann and associated embryonal tumor disease loci.
C W Richard rd,Michael Boehnke,David Berg,Jack H. Lichy,T C Meeker,Elizabeth R. Hauser,Richard M. Myers,David Cox +7 more
TL;DR: This RH map should prove useful in better defining the positions of the Beckwith-Wiedemann and associated embryonal tumor disease-gene loci as well as providing more precise order information for several 11p15 genes.
Journal Article
Monte Carlo comparison of preliminary methods for ordering multiple genetic loci.
Jane M. Olson,Michael Boehnke +1 more
TL;DR: A new method which maximizes thesum of adjacent two-point maximum lod scores divided by the equivalent number of informative meioses and the previously described method which minimizes the sum of adjacent recombination fraction estimates were found to be the best overall locus-ordering methods for the situations considered, although several other methods also performed well.
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
Antigone S. Dimas,Vasiliki Lagou,Adam Barker,Joshua W. Knowles,Reedik Maegi,Marie-France Hivert,Andrea Benazzo,Denis Rybin,Anne U. Jackson,Heather M. Stringham,Ci Song,Antje Fischer-Rosinsky,Trine Welløv Boesgaard,Niels Grarup,Fahim Abbasi,Themistocles L. Assimes,Ke Hao,Xia Yang,Cécile Lecoeur,Inês Barroso,Lori L. Bonnycastle,Yvonne Boettcher,Suzannah Bumpstead,Peter S. Chines,Michael R. Erdos,J. Graessler,Peter Kovacs,Mario A. Morken,Narisu Narisu,Felicity Payne,Alena Stančáková,Amy J. Swift,Anke Toenjes,Stefan R. Bornstein,Stéphane Cauchi,Philippe Froguel,David Meyre,Peter Schwarz,Hans-Ulrich Haering,Ulf Smith,Michael Boehnke,Richard N. Bergman,Francis S. Collins,Karen L. Mohlke,Jaakko Tuomilehto,Thomas Quertemous,Lars Lind,Torben Hansen,Oluf Pedersen,Mark Walker,Andreas Pfeiffer,Joachim Spranger,Michael Stumvoll,James B. Meigs,Nicholas J. Wareham,Johanna Kuusisto,Markku Laakso,Claudia Langenberg,Josée Dupuis,Richard M. Watanabe,Jose C. Florez,Erik Ingelsson,Mark I. McCarthy,Inga Prokopenko +63 more
TL;DR: In this article, the relationship between type 2 diabetes risk variants at 37 established susceptibility loci, and indices of proinsulin processing, insulin secretion, and insulin sensitivity was examined, using additive genetic models with adjustment for sex, age, and BMI, followed by fixed-effects, inverse variance meta-analyses.
Journal ArticleDOI
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.
Tanya M. Teslovich,Daniel Seung Kim,Xianyong Yin,Alena Stančáková,Anne U. Jackson,Matthias Wielscher,Adam C. Naj,John R. B. Perry,Jeroen R. Huyghe,Heather M. Stringham,James P. Davis,Chelsea K. Raulerson,Ryan P. Welch,Christian Fuchsberger,Adam E. Locke,Xueling Sim,Peter S. Chines,Narisu Narisu,Antti J. Kangas,Pasi Soininen,Pasi Soininen,Mika Ala-Korpela,Vilmundur Gudnason,Solomon K. Musani,Marjo-Riitta Järvelin,Gerard D. Schellenberg,Elizabeth K. Speliotes,Johanna Kuusisto,Francis S. Collins,Michael Boehnke,Markku Laakso,Karen L. Mohlke +31 more
TL;DR: Five novel signals at established amino acid loci provide further insight into the molecular mechanisms of amino acid metabolism and potentially, their perturbations in disease, and are among the first applications of gene-based tests to identify new loci for amino acid levels.
Journal ArticleDOI
Modest Evidence for Linkage and Possible Confirmation of Association Between NOTCH4 and Schizophrenia in a Large Veterans Affairs Cooperative Study Sample
Andrew D. Skol,Keith A. Young,Debby Tsuang,Stephen V. Faraone,Stephen V. Faraone,S.L. Haverstock,Stephen F. Bingham,Sarita Prabhudesai,Felicitas Mena,A.S. Menon,Chang En Yu,Paul Rundell,John R. Pepple,John R. Pepple,F. Sauter,Clinton T. Baldwin,David G. Weiss,Joseph F. Collins,T. Keith,Michael Boehnke,Gerard D. Schellenberg,Ming T. Tsuang,Ming T. Tsuang +22 more
TL;DR: Test for linkage and association between the same five markers used by Wei and Hemmings in 166 families collected from a multi‐center study conducted by the Department of Veterans Affairs (DVA) Cooperative Study Program (CSP).