M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Probable Exclusion of GLC1A as a Candidate Glaucoma Gene in a Family with Middle-age-onset Primary Open-angle Glaucoma
Julia E. Richards,Paul R. Lichter,Sarah B. Herman,Elizabeth R. Hauser,Yu-Chih Hou,A. Tim Johnson,A. Tim Johnson,Michael Boehnke +7 more
TL;DR: The most likely interpretation of these observations is that a defect in the GLC1A glaucoma gene is not responsible for adult-onset primary open-angle glAUcoma in family UM:POAG1, which suggests the existence of at least two primaryOpen-angleglaucomA genes, the previously reported G LC1A gene on chromosome 1q and another gene located elsewhere in the genome.
Trans-Ethnic Fine-Mapping of Lipid Loci Identifies Population-Specific Signals and Allelic Heterogeneity That Increases the Trait Variance Explained
Ying Wu,Lindsay L. Waite,Anne U. Jackson,Wayne H-H Sheu,Steven Buyske,Devin Absher,Donna K. Arnett,Eric Boerwinkle,Lori L. Bonnycastle,Cara L. Carty,Iona Cheng,Barbara Cochran,Damien C. Croteau-Chonka,Logan Dumitrescu,Charles B. Eaton,Nora Franceschini,Xiuqing Guo,Brian E. Henderson,Lucia A. Hindorff,Eric Kim,Leena Kinnunen,Pirjo Komulainen,Wen-Jane Lee,Loic Le Marchand,Yi Lin,Jaana Lindström,Oddgeir Lingaas-Holmen,Sabrina L. Mitchell,Narisu Narisu,Jennifer G. Robinson,Fred Schumacher,Alena Stančáková,Jouko Sundvall,Yun-Ju Sung,Amy J. Swift,Wen Chang Wang,Lynne R. Wilkens,Tom Wilsgaard,Alicia M. Young,Linda S. Adair,Christie M. Ballantyne,Petra Buzkova,Aravinda Chakravarti,Francis S. Collins,David Duggan,Alan B. Feranil,Low-Tone Ho,Yi-Jen Hung,Steven C. Hunt,Kristian Hveem,Jyh-Ming Jimmy Juang,Antero Kesäniemi,Johanna Kuusisto,Markku Laakso,Timo A. Lakka,I-Te Lee,Mark Leppert,Tara C. Matise,Leena Moilanen,Inger Njølstad,Ulrike Peters,Thomas Quertermous,Rainer Rauramaa,Jerome I. Rotter,Jouko Saramies,Jaakko Tuomilehto,Matti Uusitupa,Tzung-Dau Wang,Michael Boehnke,Christopher A. Haiman,Yii-Der Ida Chen,Charles Kooperberg,Themistocles L. Assimes,Dana C. Crawford,Chao A. Hsiung,Kari E. North,Karen L. Mohlke +76 more
TL;DR: Trans-ethnic high-density genotyping and analysis confirm the presence of allelic heterogeneity, allow the identification of population-specific variants, and limit the number of candidate SNPs for functional studies.
Journal ArticleDOI
The role of environmental heterogeneity in meta-analysis of gene-environment interactions with quantitative traits.
Shi Li,Bhramar Mukherjee,Jeremy M. G. Taylor,Kenneth Rice,Xiaoquan Wen,John D. Rice,Heather M. Stringham,Michael Boehnke +7 more
TL;DR: This paper proposes to use an adaptively weighted estimator (AWE), between meta‐analysis and meta‐regression, for the interaction parameter, and concludes that without sacrificing much efficiency, the AWE uses only univariate summary statistics from each study, and bypasses issues with sharing individual level data or full covariance matrices across studies.
Journal ArticleDOI
Identification of genetic effects underlying type 2 diabetes in South Asian and European populations
Marie Loh,Weihua Zhang,Hong Kiat Ng,Katharina T Schmid,Amel Lamri,Lin Tong,Meraj Ahmad,Jung-Jin Lee,Maggie C.Y. Ng,Lauren E. Petty,Cassandra N. Spracklen,Fumihiko Takeuchi,Md. Tariqul Islam,Farzana Jasmine,Anuradhani Kasturiratne,Muhammad G. Kibriya,Karen L. Mohlke,Guillaume Paré,Gauri Prasad,Mohammad Hasan Shahriar,Miao Li Chee,H. J. Silva,James C. Engert,Hertzel C. Gerstein,K. Radha Mani,Charumathi Sabanayagam,Marijana Vujkovic,Ananda R. Wickremasinghe,Tien Yin Wong,Chittaranjan S. Yajnik,Salim Yusuf,Habibul Ahsan,Dwaipayan Bharadwaj,Sonia S. Anand,Jennifer E. Below,Michael Boehnke,Donald W. Bowden,Giriraj R. Chandak,Ching-Yu Cheng,Norihiro Kato,Anubha Mahajan,Xueling Sim,Mark I. McCarthy,Andrew P. Morris,Jaspal S. Kooner,Danish Saleheen,John C. Chambers +46 more
TL;DR: In this paper , the authors carried out a genome-wide association meta-analysis with South Asian T2D cases (n = 16,677) and controls (n= 33,856), followed by combined analyses with Europeans (neff = 231,420).
Posted ContentDOI
Genome-wide association study of 1 million people identifies 111 loci for atrial fibrillation
Jonas B. Nielsen,Rosa B. Thorolfsdottir,Lars G. Fritsche,Weichen Zhou,Morten W. Skov,Sarah E. Graham,Todd J. Herron,Shane McCarthy,Ellen M. Schmidt,Gardar Sveinbjornsson,Ida Surakka,Michael R. Mathis,Masatoshi Yamazaki,Ryan D. Crawford,Maiken Elvestad Gabrielsen,Anne Heidi Skogholt,Oddgeir L. Holmen,Maoxuan Lin,Brooke N. Wolford,Rounak Dey,Håvard Dalen,Håvard Dalen,Patrick Sulem,Jonathan H. Chung,Joshua D. Backman,David O. Arnar,Unnur Thorsteinsdottir,Aris Baras,Colm O'Dushlaine,Anders G. Holst,Xiaoquan Wen,Whitney E. Hornsby,Frederick E. Dewey,Michael Boehnke,Sachin Kheterpal,Seunggeun Lee,Hyun Min Kang,Hilma Holm,Jacob O. Kitzman,Jordan A. Shavit,José Jalife,Chad M. Brummett,Tanya M. Teslovich,David J. Carey,Daniel F. Gudbjartsson,Kari Stefansson,Gonçalo R. Abecasis,Kristian Hveem,Cristen J. Willer +48 more
TL;DR: Experiments in rabbits with heart failure and left atrial dilation identified a heterogeneous distributed molecular switch from MYH6 to MYH7 in the left atrium, which resulted in contractile and functional heterogeneity and may predispose to initiation and maintenance of atrial arrhythmia.