M
Michael Boehnke
Researcher at University of Michigan
Publications - 540
Citations - 155551
Michael Boehnke is an academic researcher from University of Michigan. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 152, co-authored 511 publications receiving 136681 citations. Previous affiliations of Michael Boehnke include SUNY Downstate Medical Center & Norwegian University of Science and Technology.
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Journal ArticleDOI
Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk
Xianyong Yin,Debraj Bose,Annie Kwon,Sarah C. Hanks,Anne U. Jackson,Heather M. Stringham,Ryan P. Welch,Anniina Oravilahti,Lilian Fernandes Silva,Adam E. Locke,Christian Fuchsberger,S. Service,Michael R. Erdos,Lori L. Bonnycastle,Johanna Kuusisto,Nathan O. Stitziel,Ira M. Hall,Jean Morrison,Samuli Ripatti,Aarno Palotie,Nelson B. Freimer,Francis S. Collins,Karen L. Mohlke,Laura J. Scott,Eric B. Fauman,Charles F. Burant,Michael Boehnke,Markku Laakso,Xiaoquan Wen +28 more
TL;DR: In this article , the authors performed probabilistic transcriptome-wide association and locus-level colocalization analyses to integrate transcriptomics results for 49 tissues in 706 individuals from the GTEx project, metabolomics results from 1,391 plasma metabolites in 6,136 Finnish men from the METSIM study, and GWAS results for 2,861 disease traits in 260,405 Finnish individuals from FinnGen study.
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelos Evangelou,Helen R. Warren,David Mosen-Ansorena,Borbala Mifsu,Raha Pazoki,He Gao,Georgios Ntritsos,Niki Dimou,Claudia P. Cabrer,Ibrahim Karaman,Fu Liang Ng,Marina Evangelou,K. Witkowska,Evan Tzanis,Jacklyn N. Hellwege,Ayush Giri,Digna R. Velez Edwards,Yan V. Sun,Kelly Cho,J. Michael Gaziano,Peter W.F. Wilson,Philip S. Tsao,Csaba P. Kovesdy,Tõnu Esko,Reedik Mägi,Lili Milani,Peter Almgren,Thibaud Boutin,Stéphanie Debette,Jun Ding,Franco Giulianini,Elizabeth G. Holliday,Anne U. Jackson,Ruifang Li-Gao,Wei-Yu Lin,Jian'an Luan,Massimo Mangino,Christopher Oldmeadow,Bram P. Prins,Yong Qian,Muralidharan Sargurupremraj,Nabi Shah,Praveen Surendran,Sébastien Thériault,Niek Verweij,Sara M. Willems,Jing Hua Zhao,Philippe Amouyel,John M. C. Connell,Renée de Mutsert,Alex S. F. Doney,Martin Farrall,Cristina Menni,Andrew D. Morris,Raymond Noordam,Guillaume Paré,Neil Poulter,Denis C. Shields,Alice Stanton,Simon Thom,Gonçalo R. Abecasis,Najaf Amin,Dan E. Arking,Kristin L. Ayers,Caterina Barbieri,Chiara Batini,Joshua C. Bis,Tineka Blake,Murielle Bochud,Michael Boehnke,Eric Boerwinkle,Boomsma, Dorret, I,Erwin P. Bottinger,Peter S. Braund,Marco Brumat,Archie Campbell,Harry Campbell,Aravinda Chakravarti,John C. Chambers,Ganesh Chauhan,Marina Ciullo,Massimiliano Cocca,Francis S. Collins,Heather J. Cordell,Gail Davies,Martin H. de Borst,Eco J. C. de Geus,Ian J. Deary,Joris Deelen,Fabiola M. Del Greco,Cumhur Y Demirkale,Marcus Doerr,Georg Ehret,Roberto Elosua,Stefan Enroth,A. Mesut Erzurumluoglu,Teresa Ferreira,Mattias Frånberg,Oscar H. Franco,Ilaria Gandin,Paolo Gasparini,Vilmantas Giedraitis,Christian Gieger,Giorgia Girotto,Anuj Goel,Alan J. Gow,Vilmundur Gudnason,Xiuqing Guo,Ulf Gyllensten,Anders Hamsten,Tamara B. Harris,Sarah E. Harris,Catharina A. Hartman,Aki S. Havulinna,Andrew A. Hicks,Edith Hofer,Albert Hofman,Jouke-Jan Hottenga,Jennifer E. Huffman,Shih-Jen Hwang,Erik Ingelsson,Alan James,Rick Jansen,Marjo-Riitta Järvelin,Roby Joehanes,Åsa Johansson,Andrew D. Johnson,Peter K. Joshi,Pekka Jousilahti,J. Wouter Jukema,Antti Jula,Mika Kähönen,Sekar Kathiresan,Bernard Keavney,Kay-Tee Khaw,Paul Knekt,Joanne Knight,Ivana Kolcic,Jaspal S. Kooner,Seppo Koskinen,Kati Kristiansson,Zoltán Kutalik,Maris Laan,Marty Larson,Lenore J. Launer,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Li Lin,Lars Lind,Cecilia M. Lindgren,Yongmei Liu,Ruth J. F. Loos,Lorna M. Lopez,Yingchang Lu,Leo-Pekka Lyytikäinen,Anubha Mahajan,Chrysovalanto Mamasoula,Jaume Marrugat,Jonathan Marten,Yuri Milaneschi,Anna Morgan,Andrew P. Morris,Alanna C. Morrison,Peter J. Munson,Mike A. Nalls,Priyanka Nandakumar,Christopher P. Nelson,Teemu J. Niiranen,Ilja M. Nolte,Teresa Nutile,Albertine J. Oldehinkel,Ben A. Oostra,Paul F. O'Reilly,Elin Org,Sandosh Padmanabhan,Walter Palmas,Aarno Palotie,Alison Pattie,Brenda W.J.H. Penninx,Markus Perola,Annette Peters,Ozren Polasek,Peter P. Pramstaller,Quang Tri Nguyen,Olli T. Raitakari,Meixia Ren,Rainer Rettig,Kenneth Rice,Paul M. Ridker,Janina S. Ried,Harriëtte Riese,Samuli Ripatti,Antonietta Robino,Lynda M. Rose,Rotter, Jerome, I,Igor Rudan,Daniela Ruggiero,Yasaman Saba,Cinzia Sala,Veikko Salomaa,Nilesh J. Samani,Antti-Pekka Sarin,Reinhold Schmidt,Helena Schmidt,Nick Shrine,David S. Siscovick,Albert V. Smith,Harold Snieder,Siim Sõber,Rossella Sorice,John M. Starr,David J. Stott,David P. Strachan,Rona J. Strawbridge,Johan Sundström,Morris A. Swertz,Kent D. Taylor,Alexander Teumer,Martin D. Tobin,Maciej Tomaszewski,Daniela Toniolo,Michela Traglia,Stella Trompet,Jaakko Tuomilehto,Christophe Tzourio,André G. Uitterlinden,Ahmad Vaez,Peter J. van der Most,Cornelia M. van Duijn,Anne-Claire Vergnaud,Germaine C. Verwoert,Veronique Vitart,Uwe Voelker,Peter Vollenweider,Dragana Vuckovic,Hugh Watkins,Sarah H. Wild,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Jie Yao,Tatijana Zemunik,Weihua Zhang,John Attia,Adam S. Butterworth,Daniell Chasman,David Conen,Francesco Cucca,John Danesh,Caroline Hayward,Joanna M. M. Howson,Markku Laakso,Edward G. Lakatta,Claudia Langenberg,Olle Melander,Dennis O. Mook-Kanamori,Colin N. A. Palmer,Lorenz Risch,Robert A. Scott,Rodney J. Scott,Peter S. Sever,Tim D. Spector,Pim van der Harst,Nicholas J. Wareham,Eleftheria Zeggini,Daniel Levy,Patricia B. Munroe,Christopher Newton-Cheh,Morris J. Brown,Andres Metspalu,Adriana M. Hung,Christopher J. O'Donnell,Todd L. Edwards,Bruce M. Psaty,Ioanna Tzoulaki,Michael R. Barnes,Louise V. Wain,Paul Elliott,Mark J. Caulfield +279 more
TL;DR: In this paper, the authors report the largest genetic association study of blood pressure traits (systolic, diastolic and pulse pressure) to date in over 1 million people of European ancestry, identifying 535 novel blood pressure loci that not only offer new biological insights into blood pressure regulation but also highlight shared genetic architecture between blood pressure and lifestyle exposures.
Journal ArticleDOI
Linkage analysis of von Recklinghausen neurofibromatosis to DNA markers on chromosome 17
Scott R. Diehl,Michael Boehnke,Robert P. Erickson,Alexander B. Baxter,M. A. Bruce,J. L. Lieberman,D. J. Platt,L M Ploughman,K. A. Seiler,Ann M. Sweet,Francis S. Collins +10 more
TL;DR: Strong evidence of linkage of NF1 to the centromeric marker D17Z1 is reported and a weaker suggestion of linkage to the ERBA1 oncogene is reported, both at a recombination fraction of zero.
Journal ArticleDOI
Global Biobank analyses provide lessons for developing polygenic risk scores across diverse cohorts
Ying Wang,Shinichi Namba,Esteban Parra Lopera,Sini Kerminen,Kristin Tsuo,Kristi Läll,Masahiro Kanai,Weihang Zhou,Kuan-Han Wu,Marie-Julie Favé,Laxmi Bhatta,Philip Awadalla,Ben Michael Brumpton,P.M. Van Deelen,Kristian Hveem,Valeria Lo Faro,Reedik Mägi,Yoshinori Murakami,Serena Sanna,Jordan W. Smoller,Jasmina Uzunović,Brooke N. Wolford,Cristen J. Willer,Eric R. Gamazon,Nancy J. Cox,Ida Surakka,Yukinori Okada,Kuan-Han H. Wu,Humaira Rasheed,Jibril Hirbo,Ying Wang,Arjun Bhattacharya,Huiling Zhao,E. A. Lopera-Maya,Sinéad B. Chapman,Juha Karjalainen,Mitja I. Kurki,Maasha Mutaamba,Juulia Partanen,Sameer Chavan,Michelle Daya,Yi Ding,Yen-Chen Anne Feng,Christopher R. Gignoux,Sarah E. Graham,Whitney E. Hornsby,Nathan Ingold,Ruth E. Johnson,Triin Laisk,Kuang Lin,Jun Lv,Iona Y. Millwood,Priit Palta,Anita Pandit,Michael Preuss,Unnur Thorsteinsdottir,Matthew Zawistowski,Xue Zhong,Archie Campbell,Kristy Crooks,Geertruida H. de Bock,Nicholas J. Douville,Sarah Finer,Lars G. Fritsche,Chris Griffiths,Yu Guo,Karen A. Hunt,Takahiro Konuma,Riccardo E. Marioni,Jansonius Nomdo,Snehal Patil,Nicholas Rafaels,Anne Richmond,Jonathan A. Shortt,Peter Straub,Ran Tao,Brett R. Vanderwerff,Kathleen C. Barnes,Marike Boezen,Zhengming Chen,Chia-Yen Chen,Judy H. Cho,George Davey Smith,Hilary K. Finucane,Lude Franke,Andrea Ganna,Tom R. Gaunt,Tian Ge,Hailiang Huang,Jennifer E. Huffman,Jukka Koskela,Clara Lajonchere,Matthew Law,Liming Li,Cecilia M. Lindgren,Ruth J. F. Loos,Stuart MacGregor,Koichi Matsuda,Catherine M. Olsen,David J. Porteous,Jordan A. Shavit,Harold Snieder,Richard C. Trembath,Judith M. Vonk,David C. Whiteman,Stephen J. Wicks,Cisca Wijmenga,John Wright,Jie Zheng,Xiang Zhao,Michael Boehnke,Daniel H. Geschwind,Caroline Hayward,Eimear E. Kenny,Yen-Feng Lin,Hilary C. Martin,Sarah E. Medland,Aarno Palotie,Bogdan Pasaniuc,Kari Stefansson,David A. van Heel,Robin G. Walters,Sebastian Zöllner,Alicia R. Martin,Mark J. Daly,Benjamin M. Neale +125 more
TL;DR: In this article , the authors used data from Global Biobank Meta-analysis Initiative (GBMI) to explore methodological considerations and polygenic risk scores (PRSs) performance in 9 different biobanks for 14 disease endpoints.
Journal ArticleDOI
Subsets of Finns with high HDL to total cholesterol ratio show evidence for linkage to type 2 diabetes on chromosome 6q.
Corina Shtir,I. Sharon Nagakawa,William L. Duren,Karen N. Conneely,Laura J. Scott,Kaisa Silander,Timo T. Valle,Jaakko Tuomilehto,Jaakko Tuomilehto,Thomas A. Buchanan,Richard N. Bergman,Francis S. Collins,Michael Boehnke,Richard M. Watanabe +13 more
TL;DR: Results suggest two diabetes susceptibility loci on chromosome 6q that may affect subsets of individuals with a milder form of T2DM that are associated with higher HDL to total cholesterol ratio and lower fasting glucose, insulin, and C-peptide.