M
Michael D. Cahalan
Researcher at University of California, Irvine
Publications - 223
Citations - 28728
Michael D. Cahalan is an academic researcher from University of California, Irvine. The author has contributed to research in topics: T cell & Voltage-dependent calcium channel. The author has an hindex of 84, co-authored 218 publications receiving 27117 citations. Previous affiliations of Michael D. Cahalan include University of Washington & University of California, Berkeley.
Papers
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Journal ArticleDOI
STIM1, an essential and conserved component of store-operated Ca2+ channel function
Jack Roos,Paul J. Digregorio,Andriy V. Yeromin,Kari Lynn Ohlsen,Maria I. Lioudyno,Shenyuan L. Zhang,Olga Safrina,J. Ashot Kozak,Steven L. Wagner,Michael D. Cahalan,Gonul Velicelebi,Kenneth A. Stauderman +11 more
TL;DR: It is proposed that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels.
Journal ArticleDOI
STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane
Shenyuan L. Zhang,Ying Yu,Jack Roos,J. Ashot Kozak,Thomas J. Deerinck,Mark H. Ellisman,Kenneth A. Stauderman,Michael D. Cahalan +7 more
TL;DR: It is proposed that STIM1 functions as the missing link between Ca2+ store depletion and SOC influx, serving as aCa2+ sensor that translocates upon store depletion to the plasma membrane to activate CRAC channels.
Journal ArticleDOI
Two-photon imaging of lymphocyte motility and antigen response in intact lymph node.
TL;DR: Using two-photon laser microscopy to image the dynamic behavior of individual living lymphocytes deep within intact lymph nodes reveals lymphocyte behaviors that are fundamental to the initiation of the immune response.
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Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.
Shenyuan L. Zhang,Andriy V. Yeromin,Xiang Zhang,Ying Yu,Olga Safrina,Aubin Penna,Jack Roos,Kenneth A. Stauderman,Michael D. Cahalan +8 more
TL;DR: Using an unbiased genome-wide RNA interference screen in Drosophila S2 cells, 75 hits are identified that strongly inhibited Ca(2+) influx upon store emptying by thapsigargin, including Stim and olf186-F, a member of a highly conserved family of four-transmembrane spanning proteins with homologs from Caenorhabditis elegans to human.
Journal ArticleDOI
Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai
Andriy V. Yeromin,Shenyuan L. Zhang,Shenyuan L. Zhang,Weihua Jiang,Weihua Jiang,Ying Yu,Ying Yu,Olga Safrina,Olga Safrina,Michael D. Cahalan,Michael D. Cahalan +10 more
TL;DR: By site-directed mutagenesis, it is shown that a point mutation from glutamate to aspartate at position 180 in the conserved S1–S2 loop of Orai transforms the ion selectivity properties of CRAC current from being Ca2+-selective with inward rectification to being selective for monovalent cations and outwardly rectifying.