M
Michael G. McHeyzer-Williams
Researcher at Scripps Research Institute
Publications - 84
Citations - 12510
Michael G. McHeyzer-Williams is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Germinal center & B cell. The author has an hindex of 41, co-authored 81 publications receiving 12010 citations. Previous affiliations of Michael G. McHeyzer-Williams include Howard Hughes Medical Institute & Duke University.
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Journal ArticleDOI
Phenotypic Analysis of Antigen-Specific T Lymphocytes
John D. Altman,Paul Moss,Philip J. R. Goulder,Dan H. Barouch,Michael G. McHeyzer-Williams,John I. Bell,Andrew J. McMichael,Mark M. Davis +7 more
TL;DR: Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals and correlated well with cytotoxicity assays.
Journal ArticleDOI
Blimp-1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre-Plasma Memory B Cells
Miriam Shapiro-Shelef,Kuo-I Lin,Louise J. McHeyzer-Williams,Jerry Liao,Michael G. McHeyzer-Williams,Kathryn Calame +5 more
TL;DR: Mice created with a B cell-specific deletion of prdm1, the gene encoding Blimp-1, show that in response to either TD or TI antigen, serum Ig, short-lived Plasma cells, post-GC plasma cells, and plasma cells in a memory response are virtually absent, demonstrating that Blimp-1 is required for plasmacytic differentiation and Ig secretion.
Journal ArticleDOI
Antigen-specific memory b cell development
TL;DR: This work reviews the cellular and molecular regulators of this dynamic process with emphasis on the multiple memory B cell fates that develop in vivo.
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Follicular Helper T Cells: Lineage and Location
TL;DR: Understanding the regulatory functions of Tfh cells in the germinal center and the subsequent regulation of memory B cell responses to antigen recall represent the frontiers of this research area with the potential to alter fundamentally the design of future vaccines.
Journal ArticleDOI
In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines
K M Ansel,Louise J. McHeyzer-Williams,Vu N. Ngo,Michael G. McHeyzer-Williams,Jason G. Cyster +4 more
TL;DR: It is shown that CXC chemokine receptor (CXCR)5, the receptor for B lymphocyte chemoattractant (BLC), is upregulated on antigen-specific CD4 T cells in vivo when animals are immunized under conditions that promote T cell migration to follicles.