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Showing papers by "Michael G. Pollack published in 2000"


Journal ArticleDOI
TL;DR: In this article, a microactuator for rapid manipulation of discrete microdroplets is presented, which is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass.
Abstract: A microactuator for rapid manipulation of discrete microdroplets is presented. Microactuation is accomplished by direct electrical control of the surface tension through two sets of opposing planar electrodes fabricated on glass. A prototype device consisting of a linear array of seven electrodes at 1.5 mm pitch was fabricated and tested. Droplets (0.7–1.0 μl) of 100 mM KCl solution were successfully transferred between adjacent electrodes at voltages of 40–80 V. Repeatable transport of droplets at electrode switching rates of up to 20 Hz and average velocities of 30 mm/s have been demonstrated. This speed represents a nearly 100-fold increase over previously demonstrated electrical methods for the transport of droplets on solid surfaces.

1,471 citations


27 Mar 2000
TL;DR: The rationale, design, and simulation of next-generation microelectro uidic system computational architectures for the emerging eld of bioinformatics and the organization of a Uidic architecture is presented.
Abstract: This paper presents the rationale, design, and simulation of next-generationmicroelectro uidic system computational architectures for the emerging eld of bioinformatics. Current microelectro uidic processors (e.g. biochips) have largely dedicated architectures supporting relatively specialized applications. A more general microelectro uidic system computational architecture is given involving a multi-drop bus, pipelined structure. Functional requirements are explained and results of performance modeling and analysis of the micro uidic processor architecture are presented. In developing architectural concepts for micro uidics, it is instructive to \map" uidic computing concepts into electronic computing concepts to gain insight into useful organizational structures. With this linkage, issues of optimal ways to sequence data movement to affect the execution of an instruction apply to the movement of liquid to a ect the execution of a protocol. Leveraging the extensive technology base of electronic computing architecture, the organization of a uidic architecture is presented. Performance modeling and simulation studies are conducted to understand quantitatively issues of uid operations, resource utilization, and overall application throughput.