Author
Michael Garfinkle
Bio: Michael Garfinkle is an academic researcher from McGill University. The author has contributed to research in topics: Anemia & Cohort study. The author has an hindex of 2, co-authored 2 publications receiving 140 citations.
Topics: Anemia, Cohort study, Hazard ratio, Risk of mortality, Comorbidity
Papers
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TL;DR: Clinically and statistically significant increases in mortality were observed as early as at 30 days post-ACS and persisted at 1 year and anemia in patients with ACS is independently associated with a significantly increased risk of early and late mortality.
132 citations
TL;DR: PRBC transfusion in patients post-ACS undertaken at hemoglobin levels below 8.0g/dL was found to be beneficial or, at worst, neutral, and there was suggestion of harm when transfusion was undertaken athemoglobin levels above 11.0G/dL, supporting a more conservative transfusion strategy.
35 citations
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TL;DR: This work discusses how regulatory cues (e.g., iron, inflammation, or hypoxia) affect the hepcidin response and how impairment of the hePCidin/ferroportin regulatory system causes disorders of iron metabolism.
Abstract: Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron deficiency causes anemia, a major public health burden worldwide. On the other extreme, iron accumulation in critical organs such as liver, heart, and pancreas causes organ dysfunction due to the generation of oxidative stress. Therefore, systemic iron levels must be tightly balanced. Here we focus on the regulatory role of the hepcidin/ferroportin circuitry as the major regulator of systemic iron homeostasis. We discuss how regulatory cues (e.g., iron, inflammation, or hypoxia) affect the hepcidin response and how impairment of the hepcidin/ferroportin regulatory system causes disorders of iron metabolism.
144 citations
TL;DR: The use of point-of-care transfusion and coagulation management algorithms guided by viscoelastic tests based on first-line therapy with fibrinogen and prothrombin complex concentrate have been associated with reduced allogeneic blood transfusion requirements, reduced incidence of thrombotic/thromboembolic and transfusion-related adverse events, and improved outcomes in cardiac surgery.
133 citations
TL;DR: The five recommendations provide a starting point for clinicians and patients to make decisions leading to higher-quality, lower-cost care and future work is needed to promote adherence to these recommendations.
Abstract: Rationale: The high costs of health care in the United States and other developed nations are attributable, in part, to overuse of tests, treatments, and procedures that provide little to no benefit for patients. To improve the quality of care while also combating this problem of cost, the American Board of Internal Medicine Foundation developed the Choosing Wisely Campaign, tasking professional societies to develop lists of the top five medical services that patients and physicians should question.Objectives: To present the Critical Care Societies Collaborative’s Top 5 list in Critical Care Medicine and describe its development.Methods: Each professional society in the Collaborative nominated members to the Choosing Wisely task force, which established explicit criteria for evaluating candidate items, generated lists of items, performed literature reviews on each, and sought external input from content experts. Task force members narrowed the list to the Top 5 items using a standardized scoring system ba...
133 citations
TL;DR: Clinically and statistically significant increases in mortality were observed as early as at 30 days post-ACS and persisted at 1 year and anemia in patients with ACS is independently associated with a significantly increased risk of early and late mortality.
132 citations
TL;DR: There is a significant association between prior IDA and ischemic stroke and no significant relationship betweenIDA and subarachnoid/intracerebral hemorrhage even adjusting for other confounding factors.
Abstract: Background
Very little is known about the relationship between non-sickle cell anemia and stroke. The purpose of this study is to evaluate the association of iron-deficiency anemia (IDA) with stroke based on a nationwide coverage database in Taiwan.
101 citations