M
Michael H. Sieweke
Researcher at Dresden University of Technology
Publications - 80
Citations - 12002
Michael H. Sieweke is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: MAFB & Cellular differentiation. The author has an hindex of 40, co-authored 71 publications receiving 10261 citations. Previous affiliations of Michael H. Sieweke include University of California, Berkeley & Centre national de la recherche scientifique.
Papers
More filters
Journal ArticleDOI
Development of Monocytes, Macrophages, and Dendritic Cells
TL;DR: The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice.
Journal ArticleDOI
Blood monocytes: development, heterogeneity, and relationship with dendritic cells.
TL;DR: Functional characterization of monocytes is in progress in humans and rodents and will provide a better understanding of the pathophysiology of inflammation.
Journal ArticleDOI
Microglia development follows a stepwise program to regulate brain homeostasis
Orit Matcovitch-Natan,Deborah R. Winter,Amir Giladi,Stephanie Vargas Aguilar,Amit Spinrad,Sandrine Sarrazin,Sandrine Sarrazin,Sandrine Sarrazin,Hila Ben-Yehuda,Eyal David,Fabiola Zelada González,Fabiola Zelada González,Fabiola Zelada González,Pierre Perrin,Pierre Perrin,Pierre Perrin,Hadas Keren-Shaul,Meital Gury,David Lara-Astaiso,Christoph A. Thaiss,Merav Cohen,Keren Bahar Halpern,Kuti Baruch,Aleksandra Deczkowska,Erika Lorenzo-Vivas,Shalev Itzkovitz,Eran Elinav,Michael H. Sieweke,Michal Schwartz,Ido Amit +29 more
TL;DR: It is found that microglia from germ-free mice exhibited dysregulation of dozens of genes associated with the adult phase and immune response, including MAFB, which led to disruption of homeostasis in adulthood and increased expression of interferon and inflammation pathways.
Journal ArticleDOI
Beyond stem cells: self-renewal of differentiated macrophages.
TL;DR: These findings challenge the classical view of tissue maintenance by adult tissue-specific stem cells and indicate that stem cell–like self-renewal mechanisms may be activated in mature differentiated cells.
Journal ArticleDOI
Progressive replacement of embryo-derived cardiac macrophages with age
Kaaweh Molawi,Yochai Wolf,Prashanth K. Kandalla,Jeremy Favret,Jeremy Favret,Jeremy Favret,Nora Hagemeyer,Kathrin Frenzel,Alexander R. Pinto,Kay Klapproth,Sandrine Henri,Sandrine Henri,Sandrine Henri,Bernard Malissen,Bernard Malissen,Bernard Malissen,Hans Reimer Rodewald,Nadia Rosenthal,Marc Bajénoff,Marc Bajénoff,Marc Bajénoff,Marco Prinz,Steffen Jung,Michael H. Sieweke +23 more
TL;DR: Over time, the heart is progressively reconstituted with bone marrow–derived macrophages, even in the absence of inflammation.