M
Michael J. Donovan
Researcher at Hunan University
Publications - 16
Citations - 1783
Michael J. Donovan is an academic researcher from Hunan University. The author has contributed to research in topics: Aptamer & Systematic evolution of ligands by exponential enrichment. The author has an hindex of 9, co-authored 16 publications receiving 1461 citations. Previous affiliations of Michael J. Donovan include University of Florida.
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Journal ArticleDOI
Aptamers from Cell-Based Selection for Bioanalytical Applications
TL;DR: This research presents a novel probabilistic approach to genome-based approaches to personalized medicine that exploits the “cell reprograming” mechanism to characterize the immune system through “disease-fighting” cells.
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Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics
Guizhi Zhu,Jing Zheng,Jing Zheng,Erqun Song,Erqun Song,Michael J. Donovan,Kejing Zhang,Chen Liu,Weihong Tan,Weihong Tan +9 more
TL;DR: Potent antitumor efficacy and reduced side effects of drugs delivered by biocompatible aptNTrs were demonstrated in a mouse xenograft tumor model, and fluorophores on nanotrains and drug fluorescence dequenching upon release allowed intracellular signaling of nanotRains and drugs.
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Programmable and Multiparameter DNA-Based Logic Platform For Cancer Recognition and Targeted Therapy
Mingxu You,Guizhi Zhu,Guizhi Zhu,Tao Chen,Tao Chen,Michael J. Donovan,Weihong Tan,Weihong Tan +7 more
TL;DR: A general approach for assembling modular logic gates to execute programmable and higher-order profiling of multiple coexisting cell-surface markers, including several found on cancer cells, with the capacity to report a diagnostic signal and/or deliver targeted photodynamic therapy is reported.
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A Controlled‐Release Nanocarrier with Extracellular pH Value Driven Tumor Targeting and Translocation for Drug Delivery
Zilong Zhao,Hong-Min Meng,Nan-Nan Wang,Michael J. Donovan,Ting Fu,Mingxu You,Zhuo Chen,Xiao-Bing Zhang,Weihong Tan +8 more
TL;DR: This pHIP is no flop: Functionalizing mesoporous silica nanoparticles with pHLIPss peptide provides a controlled-release nanoparticle drug delivery system targeting the acidic tumor microenvironment.
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Nucleic acid aptamers: an emerging frontier in cancer therapy
Guizhi Zhu,Mao Ye,Michael J. Donovan,Erqun Song,Erqun Song,Zilong Zhao,Weihong Tan,Weihong Tan +7 more
TL;DR: The development and biomedical application of nucleic acid aptamers are discussed, with emphasis on cancer cell aptamer isolation, targeted cancer therapy, oncology biomarker identification and drug discovery.