M
Michael J. Haykinson
Researcher at University of California, Los Angeles
Publications - 13
Citations - 643
Michael J. Haykinson is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Hin recombinase & Invertasome. The author has an hindex of 10, co-authored 13 publications receiving 610 citations.
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Journal ArticleDOI
The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.
TL;DR: This study shows that HMG1 and HMG2 can substitute for the prokaryotic DNA-bending protein HU in promoting the assembly of the Hin invertasome, an intermediate structure in Hin-mediated site-specific DNA inversion.
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Communication between Hin recombinase and Fis regulatory subunits during coordinate activation of Hin-catalyzed site-specific DNA inversion
TL;DR: A molecular model for the invertasome structure is proposed that could contact amino acids from both Hin subunits at the dimer interface to induce a conformational change that coordinately positions the active sites close to the scissile phosphodiester bonds.
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The Hin dimer interface is critical for Fis-mediated activation of the catalytic steps of site-specific DNA inversion
TL;DR: The combined results demonstrate that the Hin dimer interface is of critical importance for the activation of catalysis and imply that interactions with the Fis-bound enhancer may trigger a conformational adjustment within the region that is important for concerted DNA cleavage within both recombination sites, and possibly for the subsequent exchange of DNA strands.
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Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer
Marlena S. Fejzo,Lee Anderson,Erika von Euw,Ondrej Kalous,Nuraly K. Avliyakulov,Michael J. Haykinson,Gottfried E. Konecny,Richard S. Finn,Dennis J. Slamon +8 more
TL;DR: Results indicate that amplified ADRM1 is involved in cell proliferation, migration and survival in ovarian cancer cells, supporting a role as an oncogene and novel therapeutic target for ovarian cancer.
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Correction: Proteomic Identification of Mitochondrial Targets of Arginase in Human Breast Cancer.
Rajan Singh,Nuraly K. Avliyakulov,Melissa Braga,Michael J. Haykinson,Luis R. Martinez,Vikash Singh,Meher Parveen,Gautam Chaudhuri,Shehla Pervin +8 more
TL;DR: Two errors were introduced in the preparation of this article for publication and the title of Table 1 is missing.