M
Michael J. Lehane
Researcher at Liverpool School of Tropical Medicine
Publications - 82
Citations - 4080
Michael J. Lehane is an academic researcher from Liverpool School of Tropical Medicine. The author has contributed to research in topics: Tsetse fly & African trypanosomiasis. The author has an hindex of 37, co-authored 80 publications receiving 3591 citations. Previous affiliations of Michael J. Lehane include University of Texas Medical Branch.
Papers
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Journal ArticleDOI
RNA interference of the salivary gland nitrophorin 2 in the triatomine bug Rhodnius prolixus (Hemiptera: Reduviidae) by dsRNA ingestion or injection
Ricardo Nascimento Araújo,Adriana Santos,F. S. Pinto,Nelder F. Gontijo,Michael J. Lehane,Marcos H. Pereira +5 more
TL;DR: The findings suggest that RNAi will prove a highly valuable functional genomics technique in triatomine bugs and the finding that feeding dsRNA can induce knockdown is novel for insects.
Journal ArticleDOI
Genome sequence of the tsetse fly (Glossina morsitans ): Vector of African trypanosomiasis
Junichi Watanabe,Masahira Hattori,Matthew Berriman,Michael J. Lehane,Neil Hall,Neil Hall,Philippe Solano,Serap Aksoy,Winston Hide,Winston Hide,Yeya T. Touré,Geoffrey M. Attardo,Alistair C. Darby,Atsushi Toyoda,Christiane Hertz-Fowler,Denis M. Larkin,James Cotton,Mandy Sanders,Martin T. Swain,Michael A. Quail,Noboru Inoue,Sophie Ravel,Todd D. Taylor,Tulika P. Srivastava,Vineet K. Sharma,Wesley C. Warren,Richard K. Wilson,Yutaka Suzuki,Daniel Lawson,Daniel S.T. Hughes,Karyn Megy,Daniel K. Masiga,Paul O. Mireji,Immo A. Hansen,Jan Van Den Abbeele,Joshua B. Benoit,Joshua B. Benoit,Kostas Bourtzis,Kostas Bourtzis,Kostas Bourtzis,George F. Obiero,George F. Obiero,Hugh M. Robertson,Jeffery W. Jones,Jing-Jiang Zhou,Linda M. Field,Markus Friedrich,Steven G. Nyanjom,Erich Loza Telleria,Guy Caljon,José M. C. Ribeiro,Alvaro Acosta-Serrano,Cher-Pheng Ooi,Clair Rose,David P. Price,Lee R. Haines,Alan Christoffels,Cheolho Sim,Daphne Q.-D. Pham,David L. Denlinger,Dawn L. Geiser,Irene Omedo,Joy J. Winzerling,Justin T. Peyton,Kevin K. Marucha,Mario Jonas,Megan E. Meuti,Neil D. Rawlings,Qirui Zhang,Rosaline W. Macharia,Rosaline W. Macharia,Veronika Michalkova,Veronika Michalkova,Zahra Jalali Sefid Dashti,Aaron A. Baumann,Gerd Gäde,Heather G. Marco,Jelle Caers,Liliane Schoofs,Michael A. Riehle,Wanqi Hu,Zhijian Tu,Aaron M. Tarone,Anna R. Malacrida,Caleb K. Kibet,Francesca Scolari,J.J.O. Koekemoer,Judith H. Willis,Ludvik M. Gomulski,Marco Falchetto,Maxwell J. Scott,Shuhua Fu,Sing-Hoi Sze,Thiago Luiz,Brian L. Weiss,Deirdre Walshe,Jingwen Wang,Mark Wamalwa,Mark Wamalwa,Sarah Mwangi,Urvashi N. Ramphul,Anna K. Snyder,Corey L. Brelsfoard,Gavin H. Thomas,George Tsiamis,Peter Arensburger,Rita V. M. Rio,Sandy J. Macdonald,Sumir Panji,Sumir Panji,Adele Kruger,Alia Benkahla,Apollo Simon Peter Balyeidhusa,Atway R. Msangi,Chinyere K. Okoro,Dawn Stephens,Eleanor J Stanley,Feziwe Mpondo,Florence N. Wamwiri,Furaha Mramba,Geoffrey H. Siwo,George Githinji,Gordon William Harkins,Grace Murilla,Heikki Lehväslaiho,Imna I. Malele,Joanna E. Auma,Johnson Kinyua,Johnson O. Ouma,Loyce M. Okedi,Lucien Manga,Martin Aslett,Mathurin Koffi,Michael W. Gaunt,Mmule Makgamathe,Nicola Mulder,Oliver Manangwa,Patrick P. Abila,Patrick Wincker,Richard Gregory,Rosemary Bateta,Ryuichi Sakate,Sheila C. Ommeh,Stella Lehane,Tadashi Imanishi,Victor Chukwudi Osamor,Yoshihiro Kawahara,Yoshihiro Kawahara +147 more
TL;DR: The sequence and annotation of the 366-megabase Glossina mors Titans morsitans genome are described, providing a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
Journal ArticleDOI
Tsetse immune responses and trypanosome transmission: Implications for the development of tsetse-based strategies to reduce trypanosomiasis
TL;DR: In this article, the authors describe three antimicrobial peptide genes, attacin, defensin, and diptericin, from tsetse fat body tissue obtained by subtractive cloning after immune stimulation with Escherichia coli and trypanosomes.
Book ChapterDOI
Interactions between tsetse and trypanosomes with implications for the control of trypanosomiasis.
TL;DR: The known biology of trypanosome development in the fly is reviewed in the context of the physiology of the digestive system and interactions of the immune defences and symbiotic flora.
Journal ArticleDOI
Prolonged gene knockdown in the tsetse fly Glossina by feeding double stranded RNA.
TL;DR: It is demonstrated, at transcript and protein level, that delivering dsRNA in the bloodmeal to Glossina morsitans mors Titans is as effective as injection in knockdown of the immunoresponsive midgut‐expressed gene TsetseEP.