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Michael J. Pagliassotti
Researcher at Colorado State University
Publications - 108
Citations - 7187
Michael J. Pagliassotti is an academic researcher from Colorado State University. The author has contributed to research in topics: Insulin & Insulin resistance. The author has an hindex of 45, co-authored 108 publications receiving 6719 citations. Previous affiliations of Michael J. Pagliassotti include Vanderbilt University & Arizona State University.
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Journal ArticleDOI
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells
TL;DR: It is demonstrated that saturated fatty acids disrupt endoplasmic reticulum homeostasis and induce apoptosis in liver cells via mechanisms that do not involve ceramide accumulation.
Journal ArticleDOI
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice.
William L. Holland,Benjamin T. Bikman,Liping Wang,Guan Yuguang,Katherine M. Sargent,Sarada Bulchand,Trina A. Knotts,Guanghou Shui,Deborah J. Clegg,Markus R. Wenk,Michael J. Pagliassotti,Philipp E. Scherer,Scott A. Summers,Scott A. Summers,Scott A. Summers +14 more
TL;DR: It is shown here that TLR4 is an upstream signaling component required for saturated fatty acid-induced ceramide biosynthesis, and that sphingolipids such as ceramide might be key components of the signaling networks that link lipid-induced inflammatory pathways to the antagonism of insulin action that contributes to diabetes.
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Saturated Fatty Acids Promote Endoplasmic Reticulum Stress and Liver Injury in Rats with Hepatic Steatosis
TL;DR: It is shown that hepatic steatosis characterized by increased saturated fatty acids is associated with increased liver injury and markers of endoplasmic reticulum stress, and the composition of fatty acids in the steatotic liver is an important determinant of susceptibility to liver injury.
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Fuel metabolism in men and women during and after long-duration exercise
TL;DR: The view that different priorities are placed on lipid and carbohydrate oxidation during exercise in men and women is supported and that these gender-based differences extend to the catecholamine response to exercise.
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The role of fatty acids in the development and progression of nonalcoholic fatty liver disease
TL;DR: Data suggest that saturated fatty acids may represent an intrinsic second hit to the liver that hastens the development of NASH.