M
Michael Kapinsky
Researcher at Beckman Coulter
Publications - 5
Citations - 451
Michael Kapinsky is an academic researcher from Beckman Coulter. The author has contributed to research in topics: Transplantation & Antibody. The author has an hindex of 3, co-authored 5 publications receiving 291 citations.
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Journal ArticleDOI
Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
Birgit Sawitzki,Paul N. Harden,Petra Reinke,Aurélie Moreau,James A. Hutchinson,David Game,Qizhi Tang,Eva C. Guinan,Manuela Battaglia,William J. Burlingham,Ian S.D. Roberts,Mathias Streitz,Régis Josien,Carsten A. Böger,Cristiano Scottà,James F. Markmann,Joanna Hester,Karsten Juerchott,Cécile Braudeau,Ben James,Ben James,Laura Contreras-Ruiz,Jeroen B. van der Net,Tobias Bergler,Rossana Caldara,William Petchey,Matthias Edinger,Matthias Edinger,Nathalie Dupas,Michael Kapinsky,Ingrid Mutzbauer,Ingrid Mutzbauer,Natalie M Otto,Robert Öllinger,Maria P. Hernandez-Fuentes,Fadi Issa,Norbert Ahrens,Christoph Meyenberg,Sandra Karitzky,Ulrich Kunzendorf,Stuart J. Knechtle,Josep M. Grinyó,Peter J. Morris,Peter J. Morris,Leslie Brent,A. Bushell,Laurence A. Turka,Jeffrey A. Bluestone,Robert I. Lechler,Hans J. Schlitt,M. C. Cuturi,Stephan Schlickeiser,P Friend,Tewfik Miloud,Alexander Scheffold,Antonio Secchi,Kerry Crisalli,Sang-Mo Kang,Rachel Hilton,Bernhard Banas,Gilles Blancho,Hans-Dieter Volk,Giovanna Lombardi,Kathryn J. Wood,Edward K. Geissler,Edward K. Geissler,Edward K. Geissler +66 more
TL;DR: In this paper, the authors evaluated the safety of regulatory CBMPs when combined with reduced immunosuppressive treatment in kidney transplant patients and found that CBMP is achievable and safe in living-donor kidney transplant recipients, and is associated with fewer infectious complications, but similar rejection rates in the first year.
Journal ArticleDOI
Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study
Mathias Streitz,Tewfik Miloud,Michael Kapinsky,Michael R Reed,Robert T. Magari,Edward K. Geissler,James A. Hutchinson,Katrin Vogt,Stephan Schlickeiser,Anders Handrup Kverneland,Christian Meisel,Hans-Dieter Volk,Birgit Sawitzki +12 more
TL;DR: The ONE Study panel may be adopted as a standardized method for monitoring patients in clinical trials enrolling transplant patients, particularly trials of novel tolerance promoting therapies, to facilitate fair and meaningful comparisons between trials.
Journal ArticleDOI
Advanced flowcytometric analysis of regulatory T cells: CD127 downregulation early post stem cell transplantation and altered Treg/CD3(+)CD4(+)-ratio in severe GvHD or relapse.
Melanie Bremm,Sabine Huenecke,Thomas Lehrnbecher,Eva Ponstingl,Regine Mueller,Annekathrin Heinze,Gesine Bug,Andrea Quaiser,Michael Kapinsky,Claudia Brehm,Peter Bader,Gisbert Schneider,Thomas Klingebiel,Ulrike Koehl +13 more
TL;DR: The results showed for the first time a downregulation of CD127 expression on T cells including Tregs in patients early post-SCT, and new insights into the recovery of T Regs regarding GvHD and relapse were provided.
Journal ArticleDOI
Advanced Flow Cytometry Assays for Immune Monitoring of CAR-T Cell Applications.
Ulrich Blache,Ronald Weiss,Andreas Boldt,Michael Kapinsky,André-René Blaudszun,Andrea Quaiser,Annabelle Pohl,Tewfik Miloud,Mégane Burgaud,Vladan Vucinic,Uwe Platzbecker,Ulrich Sack,Stephan Fricke,Ulrike Koehl,Ulrike Koehl,Ulrike Koehl +15 more
TL;DR: In this article, the authors established standardized 13-colour/15-parameter flow cytometry assays that are suitable to characterize immune cell subpopulations in the peripheral blood during CAR-T cell treatment.
Journal ArticleDOI
Development of a Flow Cytometry Assay to Predict Immune Checkpoint Blockade-Related Complications
Hannah-Lou Schilling,Gunther Glehr,Michael Kapinsky,Norbert Ahrens,Paloma Riquelme,Laura Cordero,F Bitterer,Hans J. Schlitt,Edward K. Geissler,Sebastian Haferkamp,James A. Hutchinson,Katharina Kronenberg +11 more
TL;DR: In this article, a 10-color flow cytometry panel was developed and validated for reliably quantifying CD4+ TEM cells and other biomarkers of irAE risk in peripheral blood samples.