M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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NF-κB and the link between inflammation and cancer.
TL;DR: In all malignancies, NF‐κB acts in a cell type‐specific manner: activating survival genes within cancer cells and inflammation‐promoting genes in components of the tumor microenvironment, yet, the complex biological functions of NF-κB have made its therapeutic targeting a challenge.
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The regulation of transcription by phosphorylation
Tony Hunter,Michael Karin +1 more
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Inflammation meets cancer, with NF-κB as the matchmaker
Yinon Ben-Neriah,Michael Karin +1 more
TL;DR: Although it seems to fulfill a distinctly tumor-promoting role in many types of cancer, NF-κB has a confounding role in certain tumors.
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Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity
TL;DR: The results show that the hypothalamic IKKbeta/NF-kappaB program is a general neural mechanism for energy imbalance underlying obesity and suggest that suppression of IKK beta either broadly across the brain or locally within the mediobasal hypothalamus, or specifically in hypothalamic AGRP neurons significantly protects against obesity and glucose intolerance.
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Intracellular pattern recognition receptors in the host response
TL;DR: It is apparent that Toll-like receptors, a class of membrane receptors that sense extracellular microbes and trigger anti-pathogen signalling cascades, are likely to have critical roles in health and disease.