M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
Papers
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Journal Article
The IL-23 to IL-17 cascade inflammation-related cancers.
Kepeng Wang,Michael Karin +1 more
TL;DR: Findings suggest that IL-23 and/or IL-17A inhibitors should be evaluated for their therapeutic and preventative potential in human cancers, especially in colorectal cancer.
Journal ArticleDOI
IKKα Is a p63 Transcriptional Target Involved in the Pathogenesis of Ectodermal Dysplasias
Barbara Marinari,Costanza Ballarò,Maranke I. Koster,Maria Laura Giustizieri,Francesca Moretti,Francesca Crosti,Marina Papoutsaki,Michael Karin,Stefano Alemà,Sergio Chimenti,Dennis R. Roop,Antonio Costanzo +11 more
TL;DR: The data demonstrate that a failure to properly express IKKalpha may play a role in the development of ectodermal dysplasias and identify I-kappaB kinase alpha (IKKalpha) as a direct transcriptional target of p63 that is induced at early phases of terminal differentiation of primary keratinocytes.
Journal ArticleDOI
Epithelial Cell IκB-Kinase β Has an Important Protective Role in Clostridium difficile Toxin A-Induced Mucosal Injury
Sungwon Chae,Lars Eckmann,Yukiko Miyamoto,Charalabos Pothoulakis,Michael Karin,Martin F. Kagnoff +5 more
TL;DR: It is concluded that activation of intestinal epithelial cell NF-κB by toxin A plays an important host mucosal protective role after C. difficile toxin A exposure that is mediated, at least in part, through promoting epithelialcell survival by abrogating epithel cell apoptosis.
Journal ArticleDOI
Obesity, autophagy and the pathogenesis of liver and pancreatic cancers
TL;DR: The relationships between autophagy, nuclear factor‐κB signaling and obesity in hepatocellular carcinoma will be discussed, as well as the dual role of Autophagy in pancreatic ductal adenocarcinoma.
Book ChapterDOI
Signaling pathways leading to nuclear factor-kappa B activation.
Nanxin Li,Michael Karin +1 more
TL;DR: This chapter focuses on studying signaling pathways triggered by a stimulus (e.g., UVA) that ultimately lead to NF-KB activation.