M
Michael Karin
Researcher at University of California, San Diego
Publications - 753
Citations - 246120
Michael Karin is an academic researcher from University of California, San Diego. The author has contributed to research in topics: IκB kinase & Signal transduction. The author has an hindex of 236, co-authored 704 publications receiving 226485 citations. Previous affiliations of Michael Karin include Sanford-Burnham Institute for Medical Research & University of California, Los Angeles.
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A single amino acid change in CUP2 alters its mode of DNA binding.
TL;DR: It is suggested that CUP2 has a complex Cu-coordinated DNA-binding domain containing different parts that function as DNA- binding elements recognizing distinct sequence motifs embedded within the UASc.
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Oncogene at last--c-Jun promotes liver cancer in mice.
Shin Maeda,Michael Karin +1 more
TL;DR: Evidence is provided that c-Jun expression is critical for induction of liver cancer by a classical protocol of tumor initiation—tumor promotion by Eferl et al.
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Roles of tumor suppressors in regulating tumor-associated inflammation.
L Yang,Michael Karin +1 more
TL;DR: This review sets forth the concept that TS can also suppress tumor-associated inflammation, a concept that provides new insights into tumor–host interactions and proposes that in some cases the loss of TS function in cancer can be overcome through inhibition of the resulting inflammatory response.
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Critical role for IL-1β in DNA damage-induced mucositis
Naama Kanarek,Sergei I. Grivennikov,Michael Leshets,Audrey Lasry,Irit Alkalay,Elad Horwitz,Yoav D. Shaul,Yoav D. Shaul,Matthew D. Stachler,Elena Voronov,Ron N. Apte,Michele Pagano,Michele Pagano,Eli Pikarsky,Michael Karin,Sankar Ghosh,Yinon Ben-Neriah +16 more
TL;DR: It is proposed that anti-IL-1β preventive treatment may ameliorate mucositis, as well as multiple disorders associated with epithelial barrier permeability, including burn injuries, head and neck trauma, alcoholic intoxication, and graft-vs-host disease.
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Genetic dissection of antigen receptor induced-NF-κB activation
TL;DR: This review addresses the cell signaling from antigen receptors as well as Toll-like receptors to NF-kappaB in both innate and adaptive immunity as revealed by the analysis of mice lacking specific signaling intermediates.